US 9,808,502 B2
Polypeptides binding to human complement C5
Charlotta Berghard, Stockholm (SE); Magnus Berglund, Vendelso (SE); Patrik Strömberg, Sollentuna (SE); Malin Lindborg, Saltsjo-Boo (SE); Elin Gunneriusson, Saltsjobaden (SE); and Joachim Feldwisch, Tyreso (SE)
Assigned to Swedish Orphan Biovitrum AB (publ), Stockholm (SE)
Appl. No. 14/378,522
Filed by Swedish Orphan Biovitrum AB (publ), Stockholm (SE)
PCT Filed Feb. 19, 2013, PCT No. PCT/SE2013/050139
§ 371(c)(1), (2) Date Aug. 13, 2014,
PCT Pub. No. WO2013/126006, PCT Pub. Date Aug. 29, 2013.
Claims priority of application No. 1250145 (SE), filed on Feb. 20, 2012.
Prior Publication US 2015/0011474 A1, Jan. 8, 2015
Int. Cl. A61K 38/16 (2006.01); C07K 14/00 (2006.01); C07K 14/47 (2006.01); C07K 14/195 (2006.01); C07K 14/315 (2006.01); A61K 38/00 (2006.01)
CPC A61K 38/164 (2013.01) [A61K 38/16 (2013.01); C07K 14/00 (2013.01); C07K 14/195 (2013.01); C07K 14/315 (2013.01); C07K 14/47 (2013.01); A61K 38/00 (2013.01)] 35 Claims
 
1. A C5 binding polypeptide, comprising a C5 binding motif, BM, which motif consists of an amino acid sequence selected from
i)
(SEQ ID NO: 763)
EX2X3X4A X6X7EID X11LPNL X16X17X18QW X21AFIX25 X26LX28D, 
wherein, independently of each other,
X2 is selected from H, Q, S, T and V;
X3 is selected from I, L, M and V;
X4 is selected from A, D, E, H, K, L, N, Q, R, S, T and Y;
X6 is selected from N and W;
X7 is selected from A, D, E, H, N, Q, R, S and T;
X11 is selected from A, E, G, H, K, L, Q, R, S, T and Y;
X16 is selected from N and T;
X17 is selected from I, L and V;
X18 is selected from A, D, E, H, K, N, Q, R, S and T;
X21 is selected from I, L and V;
X25 is selected from D, E, G, H, N, S and T;
X26 is selected from K and S;
X28 is selected from A, D, E, H, N, Q, S, T and Y;
and
ii) an amino acid sequence which has at least 86% identity to the sequence defined in i), wherein the polypeptide binds to C5.