US 9,808,498 B2
Flavonoid-based composition for pharmaceutical, nutritional or cosmetic use having potentiated antioxidant action
Giammaria Giuliani, Milan (IT); Anna Benedusi, Milan (IT); Barbara Marzani, Carbonara al Ticino (IT); Antonio Mascolo, Milan (IT); Antonio Limitone, Milan (IT); and Sergio Baroni, Villa D'adda (IT)
Assigned to Giuliani S.p.A., Milan (IT)
Appl. No. 14/777,181
Filed by GIULIANI S.P.A., Milan (IT)
PCT Filed Mar. 14, 2014, PCT No. PCT/EP2014/055162
§ 371(c)(1), (2) Date Sep. 15, 2015,
PCT Pub. No. WO2014/140312, PCT Pub. Date Sep. 18, 2014.
Claims priority of application No. M12013A0397 (IT), filed on Mar. 15, 2013.
Prior Publication US 2016/0030500 A1, Feb. 4, 2016
Int. Cl. A61K 36/87 (2006.01); A61K 45/06 (2006.01); A61K 31/05 (2006.01); A61K 31/353 (2006.01); A61K 36/63 (2006.01); A61K 8/49 (2006.01); A61Q 19/08 (2006.01); A61K 8/97 (2017.01); A61K 8/19 (2006.01); A61K 8/23 (2006.01); A61K 8/27 (2006.01); A61K 8/34 (2006.01); A61K 8/60 (2006.01); A61K 9/00 (2006.01); A61K 31/047 (2006.01); A61K 31/355 (2006.01); A61K 31/375 (2006.01); A61K 31/7048 (2006.01); A61K 33/04 (2006.01); A61K 33/30 (2006.01); A61K 33/34 (2006.01); A61K 36/06 (2006.01); A61Q 5/00 (2006.01); A61Q 19/00 (2006.01); A23L 33/105 (2016.01); A61Q 5/02 (2006.01); A61Q 7/00 (2006.01)
CPC A61K 36/87 (2013.01) [A23L 33/105 (2016.08); A61K 8/19 (2013.01); A61K 8/23 (2013.01); A61K 8/27 (2013.01); A61K 8/345 (2013.01); A61K 8/498 (2013.01); A61K 8/4973 (2013.01); A61K 8/602 (2013.01); A61K 8/97 (2013.01); A61K 9/0012 (2013.01); A61K 9/0014 (2013.01); A61K 31/047 (2013.01); A61K 31/05 (2013.01); A61K 31/353 (2013.01); A61K 31/355 (2013.01); A61K 31/375 (2013.01); A61K 31/7048 (2013.01); A61K 33/04 (2013.01); A61K 33/30 (2013.01); A61K 33/34 (2013.01); A61K 36/06 (2013.01); A61K 36/63 (2013.01); A61K 45/06 (2013.01); A61Q 5/00 (2013.01); A61Q 19/00 (2013.01); A61Q 19/08 (2013.01); A23V 2002/00 (2013.01); A61K 2800/522 (2013.01); A61K 2800/5922 (2013.01); A61K 2800/92 (2013.01); A61Q 5/02 (2013.01); A61Q 7/00 (2013.01)] 17 Claims
 
1. Composition for pharmaceutical use having synergistic antioxidant activity against free radicals, comprising:
a) a Vitis vinifera seed and leaf extract containing a combination of the flavonoids catechin and quercetin in a molar ratio in a range from 6:1 to 3:1, respectively, together with
b) an olive, Olea europaea L., leaf extract having a hydroxytyrosol content in a range from 1% to 30% by weight of the extract.