US 9,808,497 B2
Formulations of concentrated prunes and prebiotics as laxatives and dietary supplements
Om P Goel, Ann Arbor, MI (US)
Assigned to Jiva Pharma, Inc., Ann Arbor, MI (US)
Appl. No. 14/354,023
Filed by Jiva Pharma, Inc., Ann Arbor, MI (US)
PCT Filed Nov. 2, 2012, PCT No. PCT/US2012/063414
§ 371(c)(1), (2) Date Apr. 24, 2014,
PCT Pub. No. WO2013/067424, PCT Pub. Date May 10, 2013.
Claims priority of provisional application 61/556,252, filed on Nov. 6, 2011.
Claims priority of provisional application 61/597,799, filed on Feb. 12, 2012.
Claims priority of provisional application 61/636,067, filed on Apr. 20, 2012.
Claims priority of provisional application 61/677,662, filed on Jul. 31, 2012.
Prior Publication US 2014/0308374 A1, Oct. 16, 2014
Int. Cl. A01N 65/00 (2009.01); A61K 36/736 (2006.01); A61K 36/28 (2006.01); A61K 31/702 (2006.01); A23L 2/02 (2006.01); A23L 2/52 (2006.01); A23L 2/60 (2006.01); A61K 45/06 (2006.01); A61K 31/122 (2006.01); A61K 36/48 (2006.01); A61K 47/36 (2006.01); A23L 29/30 (2016.01); A23L 33/00 (2016.01); A23L 33/105 (2016.01); A23L 33/15 (2016.01); A23L 33/16 (2016.01); A23L 33/175 (2016.01); A23L 33/21 (2016.01); A61K 47/10 (2017.01)
CPC A61K 36/736 (2013.01) [A23L 2/02 (2013.01); A23L 2/52 (2013.01); A23L 2/60 (2013.01); A23L 29/37 (2016.08); A23L 33/105 (2016.08); A23L 33/15 (2016.08); A23L 33/16 (2016.08); A23L 33/175 (2016.08); A23L 33/21 (2016.08); A23L 33/40 (2016.08); A61K 31/122 (2013.01); A61K 31/702 (2013.01); A61K 36/28 (2013.01); A61K 36/48 (2013.01); A61K 45/06 (2013.01); A61K 47/36 (2013.01); A61K 47/10 (2013.01)] 1 Claim
 
1. A laxative formulation consisting essentially of the following components:
1)a therapeutically effective amount of prune concentrate or plum concentrate or a mixture thereof wherein any suspended insolubles have been removed from the concentrate, and the concentrate is >70 Brix (° Bx);
2)one or more added water soluble, non-digestible, prebiotic oligosaccharides, selected from inulins having 5-20 fructose units;
where the ratio of the concentrate to the added oligosaccharides is in a range from about 90%:10% to about 60%:40% by weight:
3)an added low calorie sweetener selected from sorbitol present in a ratio from about 5% to about 35% by weight of the concentrate; and
4) an added food approved antioxidant and preservative selected from citric acid present in a ratio of the antioxidant and preservative from 0.125% to about 2% by weight of the concentrate; and
the formulation is a laxative, having for a single dose 50 g-55 g or 1-2 fluid oz, of the formulation, and which is a pleasant tasting, prebiotic laxative, having the consistency of molasses without any gummy mouth feel.