US 9,808,482 B2
Sulphated hyaluronic acids as regulator agents of the cytokine activity
Devis Galesso, Abano Terme (IT); and Anna Maria Zanellato, Abano Terme (IT)
Assigned to FIDIA FARMACEUTICI S.p.A., Abano Terme (IT)
Appl. No. 13/320,015
Filed by Devis Galesso, Abano Terme (IT); and Anna Maria Zanellato, Abano Terme (IT)
PCT Filed May 11, 2010, PCT No. PCT/EP2010/003044
§ 371(c)(1), (2), (4) Date Jan. 4, 2012,
PCT Pub. No. WO2010/130466, PCT Pub. Date Nov. 18, 2010.
Claims priority of application No. PD2009A0135 (IT), filed on May 14, 2009.
Prior Publication US 2012/0101059 A1, Apr. 26, 2012
Int. Cl. A61K 31/737 (2006.01)
CPC A61K 31/737 (2013.01) 4 Claims
 
1. A method for stimulating the synthesis of IL-10 in a patient in the treatment of dermatitis wherein said patient has an IL-10 deficit; comprising administering to a patient in need thereof as the only active agent sulphated hyaluronic acid (HAS) being prepared starting from a HA having a molecular weight within one of the following ranges (a) 150,000 to 250,000 Da and (b) 500,000 to 750,000 Da, and a sulphation degree equal to 1 or 3.