US 9,808,478 B2
Control release of fat soluble antioxidants from an oral formulation and method
Steven Loyd, Lynnwood, WA (US); George Blouin, Seattle, WA (US); Newsha Farahani, Issaquah, WA (US); and Robert Burns, Seattle, WA (US)
Filed by Steven Loyd, Lynnwood, WA (US); George Blouin, Seattle, WA (US); Newsha Farahani, Issaquah, WA (US); and Robert Burns, Seattle, WA (US)
Filed on Apr. 18, 2016, as Appl. No. 15/131,888.
Claims priority of provisional application 62/149,063, filed on Apr. 17, 2015.
Prior Publication US 2017/0020908 A1, Jan. 26, 2017
Int. Cl. A61K 9/50 (2006.01); A61K 31/7048 (2006.01); A61K 9/00 (2006.01); A61K 31/353 (2006.01); A61K 45/06 (2006.01)
CPC A61K 31/7048 (2013.01) [A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 9/501 (2013.01); A61K 9/5047 (2013.01); A61K 9/5078 (2013.01); A61K 9/5089 (2013.01); A61K 31/353 (2013.01); A61K 45/06 (2013.01)] 9 Claims
 
1. An oral formulation for the controlled release of fat soluble antioxidants made up of particles, each particle comprising;
a. seed granules each made of calcium carbonate with microscopic fissures and interstitial spaces formed therein, disposed inside said microscopic fissures and said interstitial spaces are microscopic particles made of alkali metal salt, or alkali metal hydroxide;
b. a first layer made of microcrystalline cellulose and croscarmellose sodium surrounding said seed granules;
c. a second layer comprising a mixture of a fat soluble antioxidant and a polysaccharide or polypeptide binder or a polymer gel;
d. a third layer surrounding said second layer, said third layer made of microscopic alkaline earth metal salt particles mixed with an alkali metal hydroxide, microcrystalline cellulose, croscarmellose sodium binders, and a polysaccharide gel or a polymer gel; and,
e. at least one outer gel layer surrounding said third layer.