US 9,808,459 B2
Inhibitors of influenza viruses replication
Paul S. Charifson, Framingham, MA (US); Michael P. Clark, Concord, MA (US); Upul K. Bandarage, Lexington, MA (US); Randy S. Bethiel, Lexington, MA (US); John J. Court, Littleton, MA (US); Hongbo Deng, Southborough, MA (US); Ioana Davies, Arlington, MA (US); John P. Duffy, Northborough, MA (US); Luc J. Farmer, Montreal (CA); Huai Gao, Arlington, MA (US); Wenxin Gu, Concord, MA (US); Dylan H. Jacobs, South Boston, MA (US); Joseph M. Kennedy, Charlestown, MA (US); Mark W. Ledeboer, Acton, MA (US); Brian Ledford, Norton, MA (US); Francois Maltais, Tewksbury, MA (US); Emanuele Perola, Brookline, MA (US); Tiansheng Wang, Concord, MA (US); M. Woods Wannamaker, Stow, MA (US); Randal Byrn, Wayland, MA (US); Yi Zhou, Lexington, MA (US); Chao Lin, Winchester, MA (US); Min Jiang, Lexington, MA (US); Steven Jones, Hyde Park, MA (US); Ursula A. Germann, Newton, MA (US); Francesco G. Salituro, Marlborough, MA (US); and Ann Dak-Yee Kwong, Cambridge, MA (US)
Assigned to Vertex Pharmaceuticals Incorporated, Boston, MA (US)
Filed by Vertex Pharmaceuticals Incorporated, Boston, MA (US)
Filed on Oct. 21, 2016, as Appl. No. 15/299,757.
Application 15/299,757 is a division of application No. 14/929,634, filed on Nov. 2, 2015, granted, now 9,518,056.
Application 14/305,393 is a division of application No. 14/098,867, filed on Dec. 6, 2013, granted, now 8,829,007, issued on Sep. 9, 2014.
Application 14/098,867 is a division of application No. 13/327,206, filed on Dec. 15, 2011, abandoned.
Application 14/929,634 is a continuation of application No. 14/305,393, filed on Jun. 16, 2014, granted, now 9,345,708, issued on May 24, 2016.
Application 13/327,206 is a continuation of application No. PCT/US2010/038988, filed on Jun. 17, 2010.
Claims priority of provisional application 61/287,781, filed on Dec. 18, 2009.
Claims priority of provisional application 61/187,713, filed on Jun. 17, 2009.
Prior Publication US 2017/0100400 A1, Apr. 13, 2017
Int. Cl. C07D 401/04 (2006.01); A61K 31/506 (2006.01)
CPC A61K 31/506 (2013.01) 8 Claims
OG exemplary drawing
 
1. A method of inhibiting the replication of influenza viruses in a biological sample or in a patient comprising administering to said biological sample or patient an effective amount of a compound having the formula

OG Complex Work Unit Drawing
or a pharmaceutically acceptable salt thereof.