US 9,808,446 B2
Method for decreasing symptoms of alcohol consumption
Gur Megiddo, M.P. Judean Hills (IL); Dalia Megiddo, M.P. Judean Hills (IL); Rina Yamin, Ganne Yohannan (IL); Yaron Ilan, Jerusalem (IL); and Shimon Amselem, Rehovot (IL)
Assigned to Alcobra Ltd., Tel Aviv (IL)
Filed by Alcobra Ltd., Tel Aviv (IL)
Filed on Apr. 3, 2015, as Appl. No. 14/678,502.
Application 14/678,502 is a continuation of application No. 12/667,272, abandoned, previously published as PCT/IL2008/000917, filed on Jul. 3, 2008.
Claims priority of application No. 184389 (IL), filed on Jul. 3, 2007; and application No. 187159 (IL), filed on Nov. 5, 2007.
Prior Publication US 2015/0209338 A1, Jul. 30, 2015
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/401 (2006.01); A61K 31/44 (2006.01); A61K 31/4015 (2006.01); A61K 31/4415 (2006.01); A61K 31/455 (2006.01); A61K 9/20 (2006.01); A61K 9/46 (2006.01); A61K 9/00 (2006.01); A61K 9/16 (2006.01); A61K 9/50 (2006.01); A61K 9/70 (2006.01); A61K 47/32 (2006.01); A61K 47/38 (2006.01)
CPC A61K 31/44 (2013.01) [A61K 9/0007 (2013.01); A61K 9/0095 (2013.01); A61K 9/1635 (2013.01); A61K 9/1652 (2013.01); A61K 9/2054 (2013.01); A61K 9/5026 (2013.01); A61K 9/7061 (2013.01); A61K 31/4015 (2013.01); A61K 31/4415 (2013.01); A61K 31/455 (2013.01); A61K 47/32 (2013.01); A61K 47/38 (2013.01)] 10 Claims
 
1. A method for increasing the mean tmax of metadoxine in the blood of a subject in need thereof comprising administering a composition for oral administration comprising as the active ingredient metadoxine, wherein a portion of the metadoxine is formulated for sustained release and a portion of the metadoxine is formulated for immediate release, and wherein the relative proportion of the sustained release metadoxine portion to the immediate release metadoxine portion is in the range of from 60:40 to 80:20, in whole integers.