US 9,808,444 B2
Methods for restoration of histamine balance
Cristian Arnou, Santa Monica, CA (US)
Assigned to BioHealthonomics Inc., Santa Monica, CA (US)
Filed by BioHealthonomics Inc., Santa Monica, CA (US)
Filed on Nov. 2, 2016, as Appl. No. 15/341,839.
Application 15/341,839 is a continuation of application No. 14/684,174, filed on Apr. 10, 2015, granted, now 9,511,054.
Application 14/684,174 is a continuation of application No. 14/315,206, filed on Jun. 25, 2014, granted, now 9,023,881, issued on May 5, 2015.
Application 14/315,206 is a continuation in part of application No. PCT/US2013/046420, filed on Jun. 18, 2013.
Claims priority of provisional application 61/733,630, filed on Dec. 5, 2012.
Claims priority of provisional application 61/867,966, filed on Aug. 20, 2013.
Claims priority of provisional application 62/002,613, filed on May 23, 2014.
Prior Publication US 2017/0266163 A1, Sep. 21, 2017
Int. Cl. A61K 31/417 (2006.01); A61K 45/06 (2006.01)
CPC A61K 31/417 (2013.01) [A61K 45/06 (2013.01)] 18 Claims
 
1. An escalating histamine dosing regimen comprising in sequential order:
a) a first dosing segment comprising two or more sequential doses of histamine separated by one or more equal time intervals (the “first time interval”), wherein the doses increase in histamine concentration from dose to dose while the administered volume of each dose stays constant; and
b) a second dosing segment comprising two or more sequential doses of histamine separated by one or more equal time intervals (the “second time interval”), wherein the doses increase in histamine concentration from dose to dose while the administered volume of each dose stays constant;
wherein the volume of each histamine dose in the second dosing segment is greater than the volume of each histamine dose in the first dosing segment, and the second time interval is longer than the first time interval.