US 9,808,429 B2
Topical drug patch including microspheres
Zhidao Xia, Swansea (GB); and Alan Marsh, Swansea (GB)
Assigned to Swansea University, Swansea (GB)
Appl. No. 14/913,540
Filed by Swansea University, Swansea (GB)
PCT Filed Aug. 18, 2014, PCT No. PCT/GB2014/000322
§ 371(c)(1), (2) Date Feb. 22, 2016,
PCT Pub. No. WO2015/025119, PCT Pub. Date Feb. 26, 2015.
Claims priority of application No. 1314909.1 (GB), filed on Aug. 21, 2013.
Prior Publication US 2016/0199314 A1, Jul. 14, 2016
Int. Cl. A61K 9/70 (2006.01); A61K 9/50 (2006.01); A61K 31/593 (2006.01); A61K 31/122 (2006.01); A61F 13/02 (2006.01)
CPC A61K 9/703 (2013.01) [A61K 9/5031 (2013.01); A61K 9/7092 (2013.01); A61K 31/122 (2013.01); A61K 31/593 (2013.01); A61F 13/0259 (2013.01)] 16 Claims
 
1. A topical drug delivery patch, comprising:
a hydrogel;
a drug delivery layer including the hydrogel and microspheres encapsulating a drug, said microspheres being carried in the hydrogel, the microspheres each formed of a solid polymer having the drug encapsulated therein;
a support layer which is attached to a first face of the drug deliver layer; and
a releasable protective layer attached to a second face of the drug delivery layer, with the releasable protective layer being removable such that in use the second face can be applied to the skin of an individual so the drug in the microspheres can be released onto the skin while the support layer forms a covering for the drug delivery layer.