US 9,808,428 B2
Compositions and methods for the delivery of therapeutics
Howard E. Gendelman, Omaha, NE (US); and Xin-Ming Liu, Omaha, NE (US)
Assigned to Board of Regents of the University of Nebraska, Lincoln, NE (US)
Appl. No. 15/111,046
Filed by The Board of Regents of the University of Nebraska, Lincoln, NE (US)
PCT Filed Jan. 14, 2015, PCT No. PCT/US2015/011364
§ 371(c)(1), (2) Date Jul. 12, 2016,
PCT Pub. No. WO2015/108945, PCT Pub. Date Jul. 23, 2015.
Claims priority of provisional application 61/927,315, filed on Jan. 14, 2014.
Prior Publication US 2016/0346222 A1, Dec. 1, 2016
Int. Cl. A61K 31/445 (2006.01); A61K 9/51 (2006.01); A61K 47/24 (2006.01); A61K 45/06 (2006.01); A61K 31/46 (2006.01)
CPC A61K 9/5153 (2013.01) [A61K 9/5123 (2013.01); A61K 31/46 (2013.01); A61K 45/06 (2013.01); A61K 47/24 (2013.01)] 25 Claims
 
1. A nanoparticle consisting of at least one CCR5 receptor antagonist, at least one hydrophobic polymer, and at least one surfactant.