US 9,808,424 B2
Method for formulating large diameter synthetic membrane vesicles
Ernest George Schutt, San Diego, CA (US); Ronald Warren McGuire, Murrieta, CA (US); Peter Andrew Walters, San Diego, CA (US); and Kathleen D. A. Los, San Diego, CA (US)
Assigned to Pacira Pharmaceuticals, Inc., San Diego, CA (US)
Filed by Pacira Pharmaceuticals, Inc., San Diego, CA (US)
Filed on Mar. 8, 2013, as Appl. No. 13/791,569.
Application 13/791,569 is a continuation of application No. 13/083,485, filed on Apr. 8, 2011.
Claims priority of provisional application 61/322,814, filed on Apr. 9, 2010.
Prior Publication US 2013/0183375 A1, Jul. 18, 2013
Int. Cl. A61K 9/48 (2006.01); B01D 1/16 (2006.01); B01J 13/02 (2006.01); A61K 9/127 (2006.01); A61K 31/4458 (2006.01); B01F 3/08 (2006.01); B01F 5/10 (2006.01); B01F 7/00 (2006.01); A61M 11/00 (2006.01); B01J 13/04 (2006.01); B01J 13/12 (2006.01); A61K 31/445 (2006.01); B01F 3/04 (2006.01); B01F 15/06 (2006.01)
CPC A61K 9/1271 (2013.01) [A61K 9/127 (2013.01); A61K 9/1277 (2013.01); A61K 9/4833 (2013.01); A61K 31/445 (2013.01); A61K 31/4458 (2013.01); A61M 11/00 (2013.01); B01D 1/16 (2013.01); B01F 3/04049 (2013.01); B01F 3/0807 (2013.01); B01F 3/088 (2013.01); B01F 5/104 (2013.01); B01F 7/0075 (2013.01); B01F 15/065 (2013.01); B01J 13/043 (2013.01); B01J 13/125 (2013.01); B01F 2015/061 (2013.01); B01F 2215/0032 (2013.01)] 15 Claims
OG exemplary drawing
 
1. An evaporation apparatus, comprising at least one atomizing nozzle apparatus and a solvent removal vessel having a top, a bottom and a circular wall for removing an organic solvent from a droplet,
wherein the circular wall has a central axis;
wherein at least one atomizing nozzle apparatus comprises:
a first fluid conduit and a second fluid conduit each having at least one entrance orifice and at least one exit orifice;
a fluid contacting chamber having a top comprising at least one entrance orifice and having a bottom comprising at least one exit orifice and connecting to the at least one exit orifice of the first fluid conduit and the at least one exit orifice of the second fluid conduit; and
a third fluid conduit having at least one entrance orifice and at least one exit orifice, wherein the third fluid conduit annularly surrounds a portion of the fluid contacting chamber, and
wherein the solvent removal vessel comprises:
a carrier gas entrance orifice;
a solvent removal gas exit orifice centrally connected to the top and comprising a gas outlet tube extending into the solvent removal vessel residing along the central axis, wherein the solvent removal gas exit orifice diameter is less than 1/10 of a diameter of the inside of the solvent removal vessel wall and the gas outlet tube is fitted with a narrowing cone and optionally an annular ring; and
a product exit orifice connected to the bottom of the solvent removal vessel.