US 9,808,423 B2
Preparation of suspension aerosol formulations
Li Li Bovet, Chapel Hill, NC (US); and Jay T. Holt, Raleigh, NC (US)
Assigned to Generics [UK] Limited, Hertfordshire (GB)
Appl. No. 11/665,093
Filed by Li Li Bovet, Chapel Hill, NC (US); and Jay T. Holt, Raleigh, NC (US)
PCT Filed Oct. 12, 2005, PCT No. PCT/GB2005/050183
§ 371(c)(1), (2), (4) Date Jun. 1, 2009,
PCT Pub. No. WO2006/040598, PCT Pub. Date Apr. 20, 2006.
Claims priority of provisional application 60/617,686, filed on Oct. 12, 2004.
Prior Publication US 2009/0297457 A1, Dec. 3, 2009
Int. Cl. A61K 9/12 (2006.01); A61M 16/10 (2006.01); A61M 15/00 (2006.01); A61K 9/10 (2006.01); A61K 9/00 (2006.01)
CPC A61K 9/10 (2013.01) [A61K 9/008 (2013.01); A61K 9/0043 (2013.01)] 59 Claims
 
1. A method of preparing a suspension aerosol formulation comprising a particulate medicament and a propellant, wherein a medicament solution is mixed with the propellant under conditions that cause a precipitate of the medicament to be formed from the solution, wherein the medicament solution is mixed with the propellant in an aerosol canister, and wherein the precipitate comprises particles of the medicament in a form suitable for use in inhalation therapy.