US 9,808,421 B2
Bioerodible silicon-based devices for delivery of therapeutic agents
Paul Ashton, Newton, MA (US); Leigh T. Canham, Malvern (GB); and Christian Barnett, Pershore (GB)
Assigned to PSIVIDA US, INC., Watertown, MA (US)
Filed by pSivida US, Inc., Watertown, MA (US)
Filed on Oct. 20, 2016, as Appl. No. 15/299,050.
Application 15/299,050 is a division of application No. 15/147,203, filed on May 5, 2016.
Application 15/147,203 is a division of application No. 13/286,788, filed on Nov. 1, 2011, granted, now 9,333,173.
Claims priority of provisional application 61/470,299, filed on Mar. 31, 2011.
Claims priority of provisional application 61/408,934, filed on Nov. 1, 2010.
Prior Publication US 2017/0035690 A1, Feb. 9, 2017
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/00 (2006.01); A61K 9/14 (2006.01); A61K 38/17 (2006.01); A61K 38/28 (2006.01); A61K 38/47 (2006.01); A61L 27/02 (2006.01); A61L 27/54 (2006.01); A61L 27/56 (2006.01); C07K 16/22 (2006.01); A61K 39/395 (2006.01)
CPC A61K 9/0051 (2013.01) [A61K 9/0024 (2013.01); A61K 9/143 (2013.01); A61K 38/1709 (2013.01); A61K 38/28 (2013.01); A61K 38/47 (2013.01); A61K 39/3955 (2013.01); A61L 27/025 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); C07K 16/22 (2013.01); A61L 2400/12 (2013.01); C12Y 302/01017 (2013.01)] 27 Claims
OG exemplary drawing
 
1. A device comprising a porous silica carrier material, wherein the carrier material comprises at least one large molecule therapeutic agent disposed in pores of the carrier material, wherein the therapeutic agent is a protein, and either:
a) the pores have an average pore size from about 15 nm to about 40 nm and the therapeutic agent has a molecular weight from about 100,000 to about 200,000 amu, or
b) the pores have an average pore size from about 25 nm to about 40 nm and the therapeutic agent has a molecular radius from about 6 nm to about 8 nm.