US 9,808,344 B2
Method for modifying the wettability and other biocompatibility characteristics of a surface of a biological material by the application of beam technology and biological materials made thereby
Joseph Khoury, Dedham, MA (US); Laurence B. Tarrant, Beverly Farms, MA (US); Sean R. Kirkpatrick, Littleton, MA (US); Richard C. Svrluga, Cambridge, MA (US); and Stephen M. Blinn, Amherst, NH (US)
Filed by Joseph Khoury, Dedham, MA (US); Laurence B. Tarrant, Beverly Farms, MA (US); Sean R. Kirkpatrick, Littleton, MA (US); Richard C. Svrluga, Cambridge, MA (US); and Stephen M. Blinn, Amherst, NH (US)
Filed on Aug. 24, 2015, as Appl. No. 14/833,402.
Application 14/833,402 is a division of application No. 13/922,787, filed on Jun. 20, 2013, granted, now 9,114,195.
Application 13/922,787 is a continuation in part of application No. PCT/US2012/051690, filed on Aug. 21, 2012.
Claims priority of provisional application 61/526,179, filed on Aug. 22, 2011.
Claims priority of provisional application 61/661,892, filed on Jun. 20, 2012.
Prior Publication US 2015/0359636 A1, Dec. 17, 2015
Int. Cl. A61F 2/28 (2006.01); A61L 27/54 (2006.01); A61L 27/36 (2006.01)
CPC A61F 2/28 (2013.01) [A61L 27/3608 (2013.01); A61L 27/54 (2013.01); A61F 2002/2817 (2013.01); A61F 2002/2835 (2013.01); A61F 2310/00359 (2013.01); A61F 2310/00976 (2013.01); A61L 2300/414 (2013.01); A61L 2430/02 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A bone shape for surgical implantation, comprising a bone surface and one or more natural bone growth factors, wherein at least a portion of the boric surface further comprises a barrier layer formed by irradiation of the portion by an accelerated and focused Neutral Beam derived from a gas-cluster ion-beam, to modify the elution rate of the one or more natural bone growth factors.