US 9,808,177 B2
Systems and methods for automated voxelation of regions of interest for magnetic resonance spectroscopy
John Patrick Claude, Redwood City, CA (US); James C. Peacock, III, San Carlos, CA (US); and Paul H. Kane, Albuquerque, NM (US)
Assigned to NOCIMED, INC., Redwood City, CA (US)
Filed by Nocimed, Inc., Redwood City, CA (US)
Filed on Mar. 4, 2016, as Appl. No. 15/61,798.
Application 15/061,798 is a continuation of application No. 13/830,632, filed on Mar. 14, 2013, granted, now 9,280,718.
Application 13/830,632 is a continuation in part of application No. PCT/US2011/062137, filed on Nov. 23, 2011.
Claims priority of provisional application 61/417,182, filed on Nov. 24, 2010.
Prior Publication US 2017/0032209 A1, Feb. 2, 2017
Int. Cl. A61B 5/055 (2006.01); G01R 33/485 (2006.01); G01R 33/54 (2006.01); G06K 9/34 (2006.01); G06T 7/12 (2017.01); A61B 5/00 (2006.01); G01R 33/483 (2006.01); G06T 7/11 (2017.01); G06T 7/62 (2017.01)
CPC A61B 5/055 (2013.01) [A61B 5/4566 (2013.01); G01R 33/485 (2013.01); G01R 33/4835 (2013.01); G01R 33/543 (2013.01); G06K 9/34 (2013.01); G06T 7/11 (2017.01); G06T 7/12 (2017.01); G06T 7/62 (2017.01); G06T 2207/10088 (2013.01); G06T 2207/30012 (2013.01)] 28 Claims
OG exemplary drawing
 
1. A method for obtaining information relating to a region of interest, the method comprising:
accessing a plurality of electronic magnetic resonance imaging (MRI) images of an area that includes a region of interest in an intervertebral disc of a spine;
for each of the plurality of electronic MRI images:
automatically processing the electronic MRI image, using one or more computer processors, to emphasize pixels associated with two opposite borders between the intervertebral disc and two superiorly and inferiorly adjacent vertebral bodies, respectively;
automatically identifying, using the one or more computer processors, a population of pixels in the electronic MRI image associated with the borders; and
automatically fitting, using the one or more computer processors, a two dimensional rectilinear shape inside a cross-section of the region of interest in the intervertebral disc and between the borders shown by the electronic MRI image based on the population of pixels;
automatically generating, using the one or more computer processors, world coordinates that define a three dimensional selected volume comprising a voxel that fits inside of the region of interest in the intervertebral disc and excludes the two superiorly and inferiorly adjacent vertebral bodies associated with the borders based on one or more of the two dimensional rectilinear shapes; and
scanning the voxel with a magnetic resonance spectroscopy (MRS) system in communication with the one or more computer processors to provide an MRS spectrum of chemical constituents within the voxel.