US 9,808,173 B2
Method for the spatially resolved determination of physcial, chemical and/or biological properties or state variables
Bernhard Gleich, Hamburg (DE)
Assigned to KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
Appl. No. 10/552,818
Filed by Bernhard Gleich, Hamburg (DE)
PCT Filed Apr. 15, 2004, PCT No. PCT/IB2004/050447
§ 371(c)(1), (2), (4) Date Oct. 11, 2005,
PCT Pub. No. WO2004/091396, PCT Pub. Date Oct. 28, 2004.
Claims priority of application No. 03101022 (EP), filed on Apr. 15, 2003.
Prior Publication US 2006/0210987 A1, Sep. 21, 2006
Int. Cl. G01N 33/48 (2006.01); A61B 5/05 (2006.01); G06F 11/07 (2006.01); A61B 5/06 (2006.01); A61K 49/18 (2006.01); G06G 7/58 (2006.01)
CPC A61B 5/0515 (2013.01) [A61B 5/06 (2013.01); A61K 49/1818 (2013.01); G06F 11/0736 (2013.01)] 24 Claims
 
1. A method for the spatially resolved determination of physical, chemical and/or biological properties or state variables, particularly substance concentrations, temperature, pH and/or physical fields, and/or the change in such physical, chemical and/or biological properties or state variables in an examination area of an examination object by determining a change in spatial distribution and/or mobility of magnetic particles in the examination area or in parts thereof as a function of the effect of physical, chemical and/or biological influencing variables on at least a part-area and/or in the physical, chemical and/or biological conditions in at least a part-area of the examination area, the method comprising:
a) introducing coated magnetic particles having a coating into at least part of the examination area,
b) generating a magnetic field with a spatial profile of the magnetic field strength such that there is produced in the examination area a first part-area having a low magnetic field strength and a second part-area having a higher magnetic field strength,
c) changing the relative spatial position of the first and second part-areas in the examination area or changing the magnetic field strength in the first part-area so that the magnetization of the particles is locally changed,
d) detecting signals that depend on magnetization in the examination area that is influenced by said changing, and
e) evaluating the signals so as to obtain information about change in the spatial distribution and/or mobility of the magnetic particles in the examination area, wherein the coating is degradable and inhibits mobility of the particles.