US 9,808,169 B2
System for electroencephalographic detection of an inadequacy between the state of a patient placed under ventilatory support and the setting of the machine used for this support, and use of this detection to adjust the setting
Thomas Similowski, Issy les Moulineaux (FR); Mathieu Raux, Paris (FR); and Louise Tyvaert, Lille (FR)
Assigned to UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), Paris (FR); ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, Paris (FR); UNIVERSITE LILLE 2 DROIT ET SANTE, Lillie (FR); and CENTRE HOSPITALIER UNIVERSITAIRE DE LILLE, Lillie (FR)
Appl. No. 13/808,424
Filed by Thomas Similowski, Issy les Moulineaux (FR); Mathieu Raux, Paris (FR); and Louise Tyvaert, Lille (FR)
PCT Filed Jul. 6, 2011, PCT No. PCT/FR2011/051611
§ 371(c)(1), (2), (4) Date Apr. 23, 2013,
PCT Pub. No. WO2012/004534, PCT Pub. Date Jan. 12, 2012.
Claims priority of application No. 10 55515 (FR), filed on Jul. 7, 2010.
Prior Publication US 2013/0204150 A1, Aug. 8, 2013
Int. Cl. A61B 5/04 (2006.01); A61B 5/048 (2006.01); A61B 5/08 (2006.01); A61M 16/00 (2006.01); G06K 9/00 (2006.01); A61B 5/00 (2006.01)
CPC A61B 5/04014 (2013.01) [A61B 5/048 (2013.01); A61B 5/08 (2013.01); A61M 16/0051 (2013.01); A61M 16/0057 (2013.01); G06K 9/00536 (2013.01); A61B 5/726 (2013.01); A61M 2205/502 (2013.01); A61M 2230/10 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A system for electroencephalographic detection of an improper adjustment of a ventilator used on a mammal, comprising:
an electroencephalograph, capable of measuring, as a function of time, an electroencephalographic signal representative of a breathing process;
an input receiving a respiratory initiation signal, different from the electroencephalographic signal, capable of indicating a respiratory initiation time;
wherein the detection system further comprises:
a beta band device specifying a sole beta frequency band comprised between 15 and 30 Hz and with a width comprised between 5 and 10 Hz;
a processor configured to:
process the measured electroencephalographic signal as it is being acquired, in the sole specified beta frequency band,
calculate the instantaneous power of the electroencephalographic signal in the sole beta frequency band, and
calculate, for each breathing cycle, from the instantaneous power, an average power of the electroencephalographic signal in the sole beta frequency band over a first interval;
memory, storing the calculated instantaneous power; and
an identifier identifying, for each breathing cycle, an improper adjustment of the ventilator from the electroencephalographic signals processed in the sole beta frequency band:
wherein the identifier comprises a comparator comparing the instantaneous power calculated in a second interval extending in advance of the respiratory initiation time with the average power calculated over the first interval, the first interval extending in advance of the second interval, and
wherein the identifier further comprises a detector, capable of detecting, for each breathing cycle, a deviation between the average power calculated in the first interval and the instantaneous power calculated in the second interval, and
wherein said deviation comprises a decrease of the instantaneous power calculated in the second interval compared to the average power calculated over the first interval and is representative of an improper adjustment of the ventilator.