US 9,808,011 B2
Pentacyclic triterpene compounds and uses thereof
John G. Riley, Crapaud (CA); and Richard J. Bethell, Charlottetown (CA)
Assigned to BIOVECTRA INC., Charlottetown (CA)
Filed by BioVectra Inc., Charlottetown (CA)
Filed on Dec. 15, 2014, as Appl. No. 14/570,333.
Prior Publication US 2016/0165892 A1, Jun. 16, 2016
Int. Cl. A01N 45/00 (2006.01); C07J 63/00 (2006.01)
CPC A01N 45/00 (2013.01) [C07J 63/008 (2013.01)] 14 Claims
1. A PEGylated bis pentacyclic triterpene having the formula:
A is a first pentacyclic triterpene;
B is a second pentacyclic triterpene; and
P is a polyethylene glycol (PEG) molecule with an average molecular weight of from about 400 daltons (Da) to about 8000 Da, for use in treating a fungal disease in a plant, wherein the fungal disease is blight;
said first and second pentacyclic triterpenes are each independently betulin, betulinic acid, or lupeol; and
A and B are each independently covalently bound to P by an ester linkage at C3 or C28.