From: Sinai Yarus [mailto: redacted] Sent: Thursday, July 31, 2014 10:02 AM To: myriad-mayo_2014 Subject: Second medical use The Office should consider the status of new uses for known drugs carefully. For example, if it were discovered (hypothetically) that aspirin in high doses could be used to restore sight to the blind, a claim might read: A method comprising: identifying a subject with severely impaired vision; and administering at least 5 grams/day of aspirin to said subject. An Examiner might find that the relationship between aspirin and sight is a "natural law" and that the claim is nothing more than an instruction to "apply it". Such an analysis does not seem inconsistent with the current interim guidelines. The question remains, are society's interests served by such a pre-emptive application section 101? The claim in question is probably both novel and non-obvious. Isn't this kind of research result exactly the type of work product the patent system is designed to encourage and protect? Readers are cautioned not to actually ingest 5 grams/day of aspirin as it is most likely toxic at such a high dose. Dr. Sinai Yarus Patent Agent (USPTO) [mailto: redacted] WWW.IPAttitude.com Phone: +972-54-55-468-53 Mailing address: POB 28 Tekoa; 90908 ISRAEL