Patent Terms Extended Under 35 USC §156

NOTE: This list is for informational purposes only and is not intended to have legal effect. Furthermore, this list does not include patents which have been extended only under § 156(e)(2) or § 156(d)(5) (patents which have only received an interim extension). A copy of the certificate of extension should be included in the "correction" section of the patent's images. All patent images can be found in the Patent Full Text and Image Database

For further information, contact Mary C. Till, at (571) 272-7755 or email mary.till@uspto.gov.

Please note that nearly all patent term extension applications are available on Public PAIR.

Additional information concerning patent expiration dates of human drug products can be obtained from the Food and Drug Administration, Center for Drug Evaluation and Research. The Patent and Exclusivity Addendum of the "Orange Book" the Approved Drug Products with Therapeutic Equivalents Evaluations includes an alphabetical listing of human drug products according to generic name with related patent information.

 

Patent No. Tradename of Product (generic name, if applicable) Original Expiration Date* Period of Extension Granted
RE27757 CARDIOVERTER (Defilbrillator System) 10/26/1988 2 years
RE30577 BEPADIN/VASCOR(bepridil hydrochloride) 6/8/1993 2 years
RE30633 DEMADEX (torsemide)  4/19/1994 5 years
RE30811 ENICAID (encainide HCl) 12/20/1994 2 years
RE30910 DEURSIL (ursodeoxycholic acid) 1/7/1992 2 years
RE31244 PINDAC (Pinacidil)  11/8/1994 2 years
RE32969 ORCOLON (polyacrylamide) 9/10/2002 931 days
RE33653 PROLEUKIN (aldesleukin) 5/21/2002 1445  days
RE34440 DIFFERIN GEL (adapalene) 3/24/2009 433 days
RE34617 OLEAN (olestra) 2/12/1996 2 years
RE34878 STARLIX (nateglide) 1/21/2008 1260 days
RE35524 ETOPOPHOS (etoposide phosphate) 8/4/2007 1017 days
RE36128 AQUEOUS ARYL FLUOROPHOSPHATE SUSPENSION  (2,2'-ethylidenebis(4,6-di-tertbutylphenyl)fluorophosphonite) 3/27/2007 1390 days
RE39128 ALTABAX Ointment (retapamulin) 10/27/2018 898 days
RE34712 LEXAPRO (escitalopram oxalate) 6/8/2009 828 days
RE36755 ENBREL  (etanercept) 3/7/2012 230 days
RE37035 PRANDIN  (repaglinide) 9/5/2006 921 days
RE37721 ZETIA (ezetimibe) 6/16/2015 497 days
RE37314 CRESTOR (rosuvastatin calcium) 6/12/2012 1305 days
RE37806  XIGRIS (drotrecogin alfa) 10/28/2014 389 days
RE38158 ProGel Pleural Air Leak Sealant  7/27/2014 5 years
RE38506 ZOLINZA (vorinostat, suberoylanilide hydroxamic acid) 11/29/2011 1316 days
RE38551 VIMPAT (lacosamide)  NDA 22-253 3/17/2017 5 years
RE39198 FANAPT (iloperidone) 11/15/2011 5 years
RE39593 Tapentadol hydrochloride 6/19/2018 1508 days
RE39820 Spiriva Handihaler (tiotropium bromide inhalation powder) 3/11/2014 1421 days
RE39941 XIAFLEX (collegenase Clostridium histolyticum) 8/22/2014 5 years
RE41783 XELJANZ (tofacitinib) 12/8/2020 5 years
RE41911 IXEMPRA (ixabepilone) 5/26/2018 856 days
RE42,353 CAPRELSA (vandetanib) 9/23/2017 1738 days
RE42152 MOZOBIL (plerixafor) 12/10/2013 5 years
RE42376 BOSULIF (bosutinib) 9/24/2019 1663 days
RE42462 LETAIRIS (ambrisentan) 10/7/2015 1026 days
RE43298 VICTRELIS (boceprevir) 2/22/2022 1034 days
RE46276 BRILINTA (ticagrelor) 12/2/2019 1794 days
RE46417 TUDORZA PRESSAIR (aclidinium bromide inhalation powder) 9/5/2020 1679 days
3,577,424 MERITAL CAPSULES (nomifensine maleate) 5/4/1988 2 years
3,632,645 TENEX (Buanfacine HCl)   1/4/1989 2 years
3,641,127 ORUDIS (Kefoprofen) 2/8/1989 2 years
3,649,691 BETAGAN (Bunolol Hydrochloride)   3/14/1989 2 years
3,652,762 VOLTARIN (diclofenac sodium)  3/28/1989 2 years
3,681,500 ATROVENT (ipratropium bromide)  8/1/1989 2 years
3,708,579 RIDAURA (auranofin)  1/2/1990 2 years
3,721,687 TEMOVATE (Clobetasol propionate)   3/20/1990 2 years
3,732,340 IFEX (ifosfamide)  5/8/1990 2 years
3,737,433 TRENTAL (pentoxyfylline)  6/5/1990 2494 days
3,786,160 EXIREL (pirbuterol acetate)  1/15/1991 2 years
3,789,832 Beta 3000 Nuclear Magnetic Resonance Scanning Device  2/5/1991 384 days
3,793,457 OCUFEN (Flurbiprofen)   2/19/1991 2 years
3,842,061 ATNATIV (antithrobin III (human)) 10/15/1991 5 years
3,856,935 Typhoid Vaccine TY21a  12/24/1989 2 years
3,857,952 SECTRAL (Acebutolol Hydrochloride)  12/17/1991 2 years
3,864,487 ETHMOZINE (moricizine hydrochloride) 2/4/1992 2 years
3,878,217 SELDANE  (terfenadine) 4/15/1992 2 years
3,885,046 WELLBUTRIN (bupropion hydrochloride)  5/20/1992 2 years
3,896,145 RIMADYL (caprofen) 7/22/1992 2 years
3,910,924 CARTROL (carteolol HCl)  10/7/1992 2 years
3,911,138 FLUSOL (perfluorodecalin)  10/7/1992 2 years
3,920,818 DORMALIN (Brand of Quazepam) 11/18/1992 2 years
3,927,046 DESOGEN (desogestrel and ethinyl estradiol) 12/16/1992 1069 days
3,929,971 Pro Osteon Coralline Hydroxyapatite Bone Void Filler 12/30/1992 2 years
3,954,872 MEXITIL (mexiletine)   5/4/1993 2 years
3,957,764 COACTIN (amdinocillin)  5/18/1993 2 years
3,962,248 CLOZARIL (Clozapine)  6/8/1993 2 years
3,962,432 AREDIA (pamidronate disodium) 6/8/1993 1133 days
3,965,143 CYTOTEC (misoprostol)  6/23/1993 2 years
3,975,512 IMAGENT GI (perfluorohexane and DMPC) 8/17/1993 2 years
3,985,758 CARDENE (nicardipine HCl)  10/12/1993 2 years
3,987,052 PROSOM (estazolam) 10/19/1993 2 years
3,998,790 LOPRESSOR OROS (metoprolol fumarate)  12/21/1993 2 years
4,001,323 ISOVUE (iopamidol) 1/4/1994 2 years
4,001,331 DALGAN (dezocine)  1/4/1994 2 years
4,005,063 LUPRON (luprolide acetate) 1/25/1994 2 years
4,005,209 TAMBOCOR (flecainide acetate)   1/25/1994 2 years
4,006,220 FIBREL (gelatin matrix implant)  2/1/1994 2 years
4,012,444 NORMODYNE/TRANDATE (labetalol hydrochloride) 3/15/1994 1600 days
4,014,986 HEXABRIX (sodium & meglumine salts of ioxaglic acid) 3/29/1994 2 years
4,024,163 NIX Creme (Permethrin)  5/17/1994 2 years
4,024,251 PRODUCIL (efrotomycin) 5/17/1994 3 years
4,027,019 ORTHO-CYCLEN (norgestimate) 5/31/1994 2 years
4,035,376 SUPROL (suprofen) 7/21/1994 2 years
4,046,878 IDAMYCIN (idarubicin HCl)  9/6/1994 2 years
4,048,306 DYNABAC (dirithromycin) 9/13/1994 1626 days
4,051,141 TICLID(ticlopidine) 9/27/1994 2 years
4,052,991 PCD Tachyarrhythmia Control Device 10/11/1994 808 days
4,055,652 SULCOSYN (sulconazole nitrate) 10/25/1994 2 years
4,056,635 DIPRIVAN (propofol)  11/1/1994 2 years
4,062,848 REMERON (mirtazapine) 6/14/1996 2 years
4,071,536 BACTROBAN Ointment (Mupirocin)  1/31/1995 2 years
4,072,746 INOCOR (amrinone lactate) 2/7/1995 1270 days
4,076,831 LODINE (etodolac) 2/28/1995 2 years
4,078,071 FEMSTAT (butoconazole nitrate)   3/7/1995 2 years
4,080,458 EQUESTROLIN (luprostiol) 3/21/1995 3 years
4,080,461 SYNANTHIC (oxfendazole) 3/21/1995 3 years
4,085,225 LUVOX (fluvoxamine maleate) 4/18/1995 2 years
4,087,544 NEURONTIN (gabapentin) 5/2/1995 1720 days
4,087,545 CESAMET (Nabilone)   5/2/1995 2 years
4,089,969 TORADOL (Ketorolac trometramine)  5/16/1995 2 years
4,096,127 Anionic Polyurethane  7/27/1993 2 years
4,100,274 ZOLADEX (goserelin acetate) 7/11/1995 2 years
4,105,783 LAC-HYDRIN  (ammonium lactate) 5/3/1994 541 days
4,138,581 TORNOLATE (bitolterol mesylate)  2/6/1996 2 years
4,140,707 PARAPLATIN (Carboplatin) 2/20/1996 916 days
4,146,029 SynchroMed Infusion Pump  12/2/1992 2 years
4,146,719 NOROXIN (Norflexacin)  3/27/1996 2 years
4,154,839 NISOCOR  (nisoldipine) 11/2/1996 2 years
4,156,724 Cefpiramide Sodium 5/29/1996 2 years
4,158,068  acesulfame potassium 6/12/1996 2 years
4,166,182 PERMAX (pergolide mesylate)  8/28/1996 2 years
4,167,574 ALFENTA  (Alfentanil hydrochloride)  9/11/1996 2 years
4,182,763 BUSPAR  (Buspirone Hydrochloride)  1/8/1997 2 years
4,188,390 CARDURA (doxazosin mesylate) 2/12/1997 2 years
4,190,584 DAYPRO (oxaprozin) 2/26/1997 2 years
4,194,047 PRIMAXIN (imipenem & cilastatin sodium)   3/18/1997 2 years
4,197,297 CORLOPAM (fenoldopam mesylate) 4/8/1999 2 years
4,199,569 STROMECTOL (ivermectin) 10/3/1997 1291 days
4,201,772 PROMIT (dextran 1) 5/6/1997 468 days
4,211,771 VIRAZOLE (ribavirin)  7/8/1997 2 years
4,215,113 FOSCAVIR (forcarnet sodium) 7/27/1997 1042 days
4,215,215 TEGISON (Etretinate) 7/29/1997 2 years
4,219,478 MYCOBUTIN (rifabutin) 4/25/1995 1406 days
4,219,559 HISMANAL (astemizole) 8/26/1997 2 years
4,220,660 MESNEX (mesna) 9/2/1997 821 days
4,224,946 NOVAFIL (polybutester surgical suture)   9/30/1997 2 years
4,231,938 MEVACOR (Lovastatin)  11/4/1997 2 years
4,234,571 SYNAREL (nafarelin acetate) 11/18/1997 2 years
4,234,579 UNASYN (Sulbactam sodium  and Ampicillin sodium)  11/18/1997 2 years
4,235,892 NUFLOR (florfenicol) 11/5/1999 3 years
4,237,068 TONOCARD TABLETS (tocainide hydrochloride) 12/2/1997 342 days
4,239,747 OSMOVIST (iotrolan)  12/16/1997 2 years
4,241,057 CERADON (cefotiam 2HCl)  12/23/1997 2 years
4,242,334 DERMATOP (prednicarbate) 12/30/1997 2 years
4,243,775 MAXON (Polyglyconate Suture)  1/6/1998 2 years
4,244,946 SUPPRELIN (histrelin acetate) 1/13/1998 2 years
4,250,113 OMNIPAQUE (iohexol)   2/10/1998 684 days
4,250,334 ULTANE (sevoflurane) 12/26/1999 5 years
4,251,532 HYTRIN  (terazosin HCl)  2/17/1998 2 years
4,252,721 REV-EYES(dapiprazole HCl) 2/24/1998 1411 days
4,252,984 BETOPTIC (betaxolol hydrochloride) 2/24/1998 552 days
4,254,129 ALLEGRA (fexofenadine HCl) 4/10/1999 679 days
4,255,431 LOSEC (omeprazole)  3/10/1998 2 years
4,258,041 FORTAZ (ceftazidime)   3/24/1998 483 days
4,258,062 ZEBETA (bisoprolol fumarate) 3/24/1998 2 years
4,260,769 CEREBYX (fosphenytoin sodium) 4/7/1998 5 years
4,263,432 CEFOTAN (cefotetan disodium)  4/21/1998 615 days
4,264,500 RIMADYL (carprofen) 2/28/2000 3 years
4,264,611 PLENDIL (felodipine) 4/28/1998 2 years
4,267,179 SPORANOX (itraconazole) 5/12/1998 2 years
4,267,320 CEFTIN TABLETS (cefuroxime axetil)  5/12/1998 2 years
4,275,063 ZINECARD (dexrazoxane) 6/23/2008 5 years
4,278,663 CYGRO (Maduramicin) ammonium 7/14/1998 3 years
4,278,689 NOVANTRONE (nitoxantrone hydrochloride) 7/14/1999 2 years
4,278,789 PIRSUE (pirlimycin hydrochloride) 7/14/1998 3 years
4,280,957 VERSED INJECTABLE (midazolam)   7/28/1998 510 days
4,282,233 CLARITIN (loratidine) 8/4/1998 2 years
4,282,251 NAFTIN (naftifine HCl) 8/4/1998 2 years
4,283,408 PEPCID (Famotidine)  8/11/1998 2 years
4,284,647 UCEPHAN (sodium phenylacetate & sodium benzoate) 8/18/1998 2 years
4,285,932 EMINASE (anistreplase)  8/25/1998 2 years
4,290,962 PANDEL (hydrocortisone cream) 3/26/1999 5 years
4,291,708 T-SCAN (probe for detecting tumors) 11/2/1999 1113 days
4,297,488 ZEFAZONE (cefmetazule Na) 10/27/1998 2 years
4,298,607 CEFMAX (cefmenoxime HCl) 11/3/1998 2 years
4,303,651 FRAGMIN (dalteparin sodium) 1/4/2000 5 years
4,307,100 NAVELBINE INJECTION (vinorelbine tartrate) 8/20/1999 1053 days
4,309,445 REDUX  (dexfenfluramine hydrochloride) 6/16/2000 1343 days
4,309,778 Total Knee Prosthetic  1/12/1999 90 days
4,312,860 EXOSURF (colfosceril palmitate) 1/26/1999 1030 days
4,313,951 COROTROPE (milrinone)  2/2/1999 2 years
4,314,081 PROZAC  (Fluoxetine HCl)  2/2/1999 2 years
4,316,472 Ventak P2 AICD System 2/23/1999 740 days
4,316,839 MAZICON (flumazenil) 2/23/1999 1468 days
4,326,052 KELCOGEL (gellan gum) 4/20/1999 2 years
4,328,592 Duromedics Cardiac Valve Prosthesis 5/11/1999 476 days
4,329,364 EULEXIN (flutamide)  5/11/1999 2 years
4,331,803 BIAXIN (clarithromycin) 5/25/1999 1465 days
4,335,121 CUTIVATE (fluticasone propionate) 6/15/1999 1004 days
4,337,201 MONPRIL (fosinopril sodium) 6/29/1999 2 years
4,338,317 SERZONE (nefazodone hydrochloride) 7/6/1997 2 years
4,343,049 MONOSTRUT Cardiac Valve Prosthesis 8/10/1999 2 years
4,344,949 ACCUPRIL (quinapril HCl) 8/17/1999 2 years
4,346,227 PRAVACHOL (pravastatin sodium) 8/24/1999 1598 days
4,347,198 Astifilcon A. Toray Soft Contact Lens 8/31/1999 146 days
4,355,032 CYTOVENE (ganciclovir sodium)  10/19/1999 1244 days
4,357,324 FLUDAR (fludarabine phosphate) 11/2/1999 2 years
4,358,449 TERAZOL 7 Vaginal Cream (Terconazole)  11/9/1999 2 years
4,359,578 PENTREX (enoxacin sequihydrate) 11/16/1999 2 years
4,360,511 SPECTAMINE (iofetamine)  11/23/1999 2 years
4,361,549 ORTHOCLONE OKT*3 (muromonab-CD3) 11/30/1999 201 days
4,362,567 TISSEEL VH KIT  (two component fibrin sealant, vapor heated kit 2/4/2000 2 years
4,364,921 ULTRAVIST (iopromide) 12/21/1999 5 years
4,369,184 LIVOSTIN (levocabastine HCl) 1/18/2000 1779 days
4,374,829 PRINIVIL (lisinopril)  2/22/2000 675 days
4,375,547 AXID (Nizatidine)  3/1/2000 2 years
4,376,858 NEUTREXIN (trimetrexate glucuronate) 3/15/2000 1286 days
4,379,785 AMARYL (glimepiride) 12/17/2000 1571 days
4,382,892 FLOXIN (ofloxacin) 5/10/2000 2 years
4,382,938 AMBIEN (zolpidem tartrate) 5/10/2000 5 years
4,387,089 PHOTOPLEX (butyl methoxy-dibeuzoylmethane) 6/7/2000 2 years
4,395,403 SANDOSTATIN (octreotide acetate) 1/26/2000 2 years
4,396,598 OPTIRAY (iversol)  8/2/2000 815 days
4,397,839 SURVANTA (beractant) 8/9/2000 1262 days
4,400,358 CARDIOGEN-82 (rubidium 82) 8/23/2000 2 years
4,404,216 DIFLUCAN (fluconazale)  9/13/2000 1128 days
4,406,899 MAXIPIME (cefepime) 3/4/2002 5 years
4,406,906 NIMOTOP (nimodipine) 9/27/2000 2 years
4,407,288 CPI Ventak PRx AICO 10/4/2000 1107 days
4,409,214 SUPRAX (cefixime)  10/11/2000 2 years
4,410,520 LOTENSIN (benazepril hydrochloride) 10/18/2000 2 years
4,412,992 COLAZAL (balsalazide disodium) 7/8/2001 5 years
4,418,208 CHOLETEC (mebrofenin)  11/29/2000 53 days
4,420,639 RELAFEN (nabumetone) 12/13/2000 2 years
4,427,663 IVOMEC EPRINEX (eprinomectin) 3/16/2002 1255 days
4,428,744 Therakos UVAR System 3/3/1999 652 days
4,430,343 EMADINE  (emedastine difumarate) 10/22/2002 1027 days
4,431,665 CATALYST 50 TYPE A MEDICATED ARTICLE 2/14/2001 3 years
4,431,829 ISMO (isosorbide mononitrate) 4/14/2001 2 years
4,435,440 Sucralose  3/6/2001 2 years
4,443,466 DORMOSEDAN (detomidine HCI)  4/17/2001 954 days
4,444,784 ZOCOR (simvastatin) 4/24/2001 1704 days
4,452,745 DECABID (indecainide hydrochloride) 6/5/2001 2 years
4,452,774 CARDIOLITE (Tc99m sestamibi) 6/5/2001 1200 days
4,452,808 REQUIP (ropinirole) 12/7/2002 5 years
4,455,297 ACEL-IMMUNE (tetanus, pertussis and diptheria vaccine) 6/19/2001 1642 days
4,457,942 BUPHENYL POWDER (sodium phenylbutyrate) 8/20/2002 2 years
4,466,972 DYNA CIRC (isradipine) 8/21/2001 2 years
4,470,972 RENORMAX (spirapril HCl) 9/11/2001 2 years
4,474,787 TILADE (nedocromil sodium) 10/2/2001 5 years
4,477,615 UVASORB 4/8/2003 5 years
4,485,088 BAPTEN (beta-aminopropionitrile fumarate) 3/26/2002 3 years
4,485,096 APLIGRAF  (graftskin) 11/27/2001 5 years
4,490,351 VITREON 3/15/2002 5 years
4,494,531 Cook Bird's Nest Vena Cava Filter  1/22/2002 459 days
4,503,067 COREG (carvedilol) 3/5/2002 5 years
4,508,729 ACEON (perindopril erbumine) 4/2/2002 1601 days
4,513,006 TOPOMAX (topiramate) 9/23/2003 5 years
4,514,390 IMMITICIDE (melarsomine dihydrochloride) 4/30/2002 1632 days
4,517,359 ZITHROMAX (azithromycin) 5/14/2002 1268 days
4,520,022 CEFZIL (cefprozil) 5/28/2002 1305 days
4,525,358 ZYRTEC (cetirizine HCl) 6/25/2002 5 years
4,526,892 DOSTINEX (cabergoline) 7/2/2002 1276 days
4,528,287 MAXAQUIN (lomefloxacin HCl) 7/9/2002 1030 days
4,529,593 GANITE (gallium nitrate injection) 7/16/2002 915 days
4,530,360 Sonic Accelerated Fracture Healing System 7/23/2002 5 years
4,535,186 EFFEXOR (venlafaxine HCl) 8/13/2002 5 years
4,536,518 ZOLOFT (sertraline hydrochloride) 8/20/2002 1228 days
4,543,954 SENSOR MODEL KELVIN 500 (pacemaker)  3/13/2001 410 days
4,544,664 DOMITOR (medetomidine) 2/11/2001 3 years
4,547,520 INTERCEPTOR (milbemycin oxime) 10/15/2002 608 days
4,552,884 MANOPLAX (flosequinan) 11/12/2002 1509 days
4,555,364 HECTOROL (lahydroxyvitamin d2) 11/1/2004 5 years
4,559,174 TRILEPTAL (oxcarbazepine) 12/17/2002 1500 days
4,559,330 DIPENTUM (olsalazine sodium) 12/17/2002 592 days
4,559,332 INSPRA (eplerenone) 4/9/2004 1219 days
4,559,334 OMNICEF Tablets (cefdinir) 12/17/2002 1601 days
4,562,073 ZOSYN (tazobactam sodium and piperacillin sodium) 7/16/2002 1344 days
4,567,264 RANEXA (ranolazine) 5/18/2003 5 years
4,572,909 NORVASC (amlodipine besylate) 2/25/2003 1252 days
4,572,912 PRELAY REZULIN (troglitazone) 8/28/2004 1534 days
4,584,305 ERGAMISOL (levamisole hydrochloride) 4/22/2003 423 days
4,585,597 ANTHELIOS SP (mexoryl SX) 6/16/2004 1455 days
4,587,258 ALTACE (ramipril) 5/6/2003 632 days
4,588,585 BETASERON (Interferon beta-1b) 5/13/2003 1516 days
4,594,401 Menicon Z contact lens 12/27/2004 1200 days
4,598,089 XENICAL (orlistat) 6/18/2004 5 years
4,599,353 XALATAN (latanoprost) 7/8/2003 1116 days
4,602,017 LAMICTAL (lamotrigine) 7/22/2003 5 years
4,604,463 CAMPTOSAR (irinotecan HCl) 7/5/2004 1141 days
4,619,921 ULTRAVATE (halobetasol propionate) 10/28/2003 415 days
4,621,077 FOSAMAX (alendronate sodium) 11/4/2003 1371 days
4,626,538 SONATA (zaleplon) 6/23/2003 1810 days
4,628,098 PREVACID (lansoprazole) 7/29/2005 1371 days
4,631,278 CLINACOX 8/1/2004 3 years
4,634,697 CEDUX (ceftibuten dihydride - oral suspension) 10/1/2004 5 years
4,636,505 CASODEX  (bicalutamide) 1/13/2004 1723 days
4,637,994 LA-15 System  (low density lipoprotein apheresis system) 12/1/2003 5 years
4,639,436 GLYSET  (miglitol) 1/27/2004 5 years
4,650,807 SEMPREX -D  (acrivastine and pseudoephedrine hydrochloride) 3/17/2004 1469 days
4,650,884 CELAXA  (citalopram hydrobromide) 8/2/2005 5 years
4,659,516 FASLODEX (fulvestrant) 10/1/2004 1166 days
4,659,716 CLARINEX (desloratadine) 4/21/2004 1074 days
4,661,491 UROXATRAL (Afluzosin hydrochloride) 5/27/2006 1697 days
4,663,318 REMINYL (galantamine  hydrobromide) 1/15/2006 1064 days
4,668,669 SYNERCID (quinupristin and dalfopristin) 1/10/2006 1333 days
4,670,444 BAYTRIL  (enrofloxacin) 12/9/2003 3 years
4,681,893 LIPITOR (atorvastatin calcium) 5/30/2006 1213 days
4,686,214 VEXOL (rimexolone) 8/11/2004 996 days
4,687,659 OMNISCAN  (gadodiamide) 8/14/2004 873 days
4,687,777 ACTOS (proglitazone) 1/17/2006 5 years
4,689,320 VITRAVENE  (fomivirsen sodium) 10/15/2004   939 days
4,689,338 ALDARA  (imiquimod) 8/25/2004 5 years
4,689,339 ANTISEDAN  (atipamezole hydrochloride) 11/25/2005 1719 days
4,690,951 PAYLEAN (ractopamine hydrochloride) 9/1/2004 3 years
4,692,435 LOVENOX  (enoxaparin sodium) 12/4/2001 1116 days
4,695,578 ZOFRAN  (ondansetron HCl) 9/22/2004 104 days
4,695,590 ACTINEX (masoprocol) 9/22/2004 712 days
4,695,623 INFERGEN  (interferon alfacon-1) 9/22/2004 5 years
4,696,949 FARESTON  (toremifene citrate) 9/29/2004 5 years
4,701,460 NUROMAX  (doxacurium Cl) 10/20/2004 137 days
4,702,253 META II, Model 1204 Cardiac Pacing System   (pacemaker)  10/27/2004 349 days
4,703,035 GEREF  (sermorelin acetate) 5/14/2002 958 days
4,703,063 FLOWMAX  (tamsulosin hydrochloride) 10/27/2004 5 years
4,703,752 Lea's Shield 8/23/2005 5 years
4,704,275 ROTASHIELD  (rhesus rotavirus (serotype 3); rhesus-human reasortant rotaviruses (serotypes 1, 2, and 4)) 8/26/2005 5 years
4,708,956 LORABID  (loracarbef) 11/24/2004 402 days
4,717,720 DIFFERIN SOLUTION (adapalene) 4/10/2006 1512 days
4,721,723 PAXIL  (paroxetine hydrochloride) 1/26/2005 702 days
4,730,000 OMNIFLOX  (temfloxacin hydrochloride) 3/8/2005 328 days
4,733,665 Palmaz Balloon-Expandable Stent 3/29/2005 182 days
4,735,801 POULVAC ST Vaccine 4/5/2005 1631 days
4,738,974 NEXIUM (esomeprazole) 4/19/2005 865 days
4,739,101 LIPIDIL  (fenofibrate) 4/19/2005 248 days
4,745,177 IPRIVASK (desirudin) 5/17/2005 5 years
4,746,680 MERIDIA  (sibutramine hydrochloride) 6/11/2002      5 years
4,753,935 CELLCEPT  (mycophenolate mofetil) 1/30/2007 824 days
4,755,534 LAMISIL CREAM  (terbinafine hydrochloride) 7/5/2005 543 days
4,757,006  Human Factor VIII -- Antihemophilic Factor Concentrate 7/12/2005 516 days
4,757,057 NORMIFLO  (ardeparin sodium) 7/12/2005 5 years
4,758,579 PROTONIX (pantoprazole sodium) 7/19/2005 5 years
4,760,071 PROSCAR  (finasteride) 7/26/2005  328 days
4,761,237 EXTRNEAL (icodextrin) 8/2/2005 1468 days
4,761,418 MIVACRON  (mivacurium chloride) 8/2/2005 173 days
4,762,710 CERTIVA  (acellular purified pertussis toxoid) 6/16/2006 1807 days
4,762,856 SUPRANE (desflurane) 8/9/2005 405 days
4,784,950 NOVOSEVEN (rhFVIIa) 11/15/2005 5 years
4,793,353 Genesis Neurostimulation system 12/27/2005 323 days
4,795,751 ZAGAM  (sparfloxacin) 10/28/2006 1195 days
4,797,413 TRUSOPT  (dorzolamde HCl) 6/30/2004 1233 days
4,798,827 SYNERCID (quinupristin and dalfopristin) 5/21/2007 1770 days
4,801,577 ANTAGON (ganirelex acetate) 2/5/2007 5 years
4,804,663 RISPERDAL  (risperdone)  2/14/2006 683 days
4,804,680 AVIAX  (semduramicin sodium) 2/14/2006 237 days
4,808,605 POSICOR  (mibefradil dihidrochloride)  11/10/2007 1130 days
4,808,614 GEMZAR  (gemcitabine HCl) 2/28/2006 1537 days
4,808,616 AROMASIN (exemestane) 7/7/2006 1729 days
4,812,561 CEDAX capsule (ceftibuten dihydrate) 7/1/2007 903 days
4,814,470 TAXOTERE  (docetaxel) 7/14/2007 1035 days
4,816,456 COGNEX  (tacrine HCl) 3/28/2006 343 days
4,816,470 IMITREX  (sumatriptan succinate)  3/28/2006 275 days
4,826,763 GLUCAGEN  (glucagon (rDNA origin)) 5/2/2006 1421 days
4,826,868 ZUBRIN (Tepoxalin) 5/29/2006 1404 days
4,830,010 MERETEK UBT  (C-labeled urea) 5/16/2006 1260 days
4,831,031 GEODON (ziprasidone HCl) 3/2/2007 5 years
4,834,757 PLIF Cage prosthetic implant 5/30/2006 1777 days
4,836,217 ALLERGEN PATCH TEST  (thin layer rapid use epicutanious (T.R.U.E.) test) 6/6/2006 899 days
4,839,342 OPTIMMUNE  (cyclosporine) 9/2/2007 700 days
4,839,350 SPECTRACEF (cefditroren pivoxil) 6/13/2006 1036 days
4,840,896 VIDREL (Choriogonadotropin (r-HCG)) 6/20/2006 1044 days
4,844,882 ALBUNEX  (albumin microspheres)   7/4/2006 220 days
4,845,075 REGRANEX  (becaplermin) 7/4/2006 1578 days
4,847,265 PLAVIX  (clopidogrel bisulfate) 2/12/1998 1374 days
4,855,290 EVOXAC (cevimeline hydrochloride) 8/8/2006 1118 days
4,859,692 ACCOLATE  (zafirlukast) 8/22/2006 1496 days
4,861,584 IVY BLOCK  (bentoquatam) 8/29/2006 1458 days
4,863,908 MONUROL (fosfomycin tromethamine) 2/23/2005 1527 days
4,866,048 DOVONEX (calcipotriene) 9/12/2006 473 days
4,867,164 NCP  (neuro cybernetic prosthesis) 9/19/2006 1781 days
4,868,112 REFACTO (novel procoagulant proteins) 9/19/2006 1258 days
4,868,908 VENTRITEX CADENCE (model V-100 tiered therapy defibrillator system) 9/19/2006 223 days
4,870,086 NAROPIN  (ropivacaine HCl injection) 11/24/2006 1400 days
4,873,259 ZYFLO  (zileuton) 2/10/2007 1398 days
4,874,794 ABREVA (docosanol) 4/28/2009 5 years
4,876,248 SKELID  (disodium tiludronate) 10/24/2006 1194 days
4,879,288 SEROQUEL  (quetiapine fumarate) 3/20/2007 1651 days
4,883,812 FLOLAN (epoprostenol sodium) 9/3/2002 1347 days
4,885,243 CUBICIN (daptomycin) 12/5/2006 1348 days
4,886,062 WIKTOR  (Prime Coronary Stent System) 10/19/2007 1347 days
4,886,808 KYTRIL  (granisetron hydrochloride) 12/12/2006 382 days
4,886,812 MIRAPEX (pramipexole dihydrochloride monohydrate) 12/12/2006 1564 days
4,894,366 PROGRAF  (tacrolimus) 1/16/2007 448 days
4,895,841 ARICEPT  (donepezil hydrocloride) 6/1/2008 888 days
4,897,255 VERLUMA  (nofetumomab) 1/20/2007 1298 days
4,898,461 AMO ARRAY  (multi-focal IOL) 6/1/2007 1557 days
4,898,724 QUADRAMET (Samarium-153 ethylenediaminetetramethylenephosphonic acid) 5/14/2007 1511 days
4,900,735 ZILMAX (zilpaterol hydrochloride) 12/11/2007 5 years
4,902,683 EXCENEL (ceftiofur HCl) 2/20/2007 460 days
4,904,769 PRECOSE (acarbose) 2/27/2007 922 days
4,906,755 ANZEMET  (dolasetron mesylate) 3/6/2007 1579 days
4,910,214 PRECEDEX 7/15/2008 5 years
4,911,920 BETAXON (levobetaxolol hydrochloride) 3/27/2007 565 days
4,916,154 CYDECTIN (moxidectin) 4/10/2007 1434 days
4,916,246 MULTIHANCE (gadobenate dimeglumine) 4/10/2007 5 years
4,927,814 BONIVA (ibandronate monosodium monohydrate) 7/9/2007 1713 days
4,933,456 TESLASCAN (magnafodipir trisodium) 6/12/2007 1628 days
4,935,437 ARIMIDEX  (anastrozole) 6/10/2008 565 days
4,935,507 OMNICEF Oral Suspension  (cefdinir) 8/8/2008 1213 days
4,937,078 SURPASS (diclofenac sodium) 8/26/2008 1748 days
4,937,234 NEUTERSOL (Zinc Gluconate) 8/10/2008 5 years
4,939,130 ZOMETA (zoledronic acid) 11/13/2007 1755 days
4,941,093 Excimed UV200LA and SVS Apex Excimer Laser Systems  7/10/2007 609 days
4,943,569 MERREM  (meropenem) 7/24/2007 1063 days
4,943,639 KEPPRA (levetiracetam) 6/6/2006 1157 days
4,947,840 INTEGRA   (artificial skin) 8/21/2007 923 days
4,948,807 EXELON 8/14/2007 5 years
4,949,718 ThermaChoice (uterine balloon therapy) 8/21/2007 605 days
4,954,126 Magic WALLSTENT  CORONARY ENDOPROTHESIS 9/4/2007 858 days
4,954,348 OXILAN  (ioxilan) 11/4/2007 839 days
4,957,924 VALTREX  (valacyclavir hydrochloride) 8/8/2008 323 days
4,958,632 KDR 401 & KDR 403 pacemaker 9/25/2007 537 days
4,959,366 TIKOSYN (dofetilide) 9/25/2007 5 years
4,961,740 RAY THREADED FUSION CAGE 10/17/1998 742 days
4,963,489 DERMAGRAFT 10/16/2007 5 years
4,966,891 XELODA  (capecitabine) 11/8/2008 796 days
4,968,514 diphenylmethane diisocynate 11/6/2007 957 days
4,976,709 HYPERION LTK system (laser thermal keratoplasty) 12/11/2007 1644 days
4,977,138 ISTODAX (romidepsin) 7/6/2009 1508 days
4,978,655 ZERIT (stavudine) 12/18/2007 189 days
4,978,672 FEMARA (letrozole)  12/18/2007 1263 days
4,980,470 TEQUIN (gatlifloxacin) 12/25/2007 721 days
4,990,517 AVELOX (moxifloxacin hydrochloride) 6/30/2009 901 days
4,996,335 LOTEMAX/ALREX (loteprednol etabonate) 2/26/2008 1473 days
4,997,841 AMERGE  (naratriplan hydrochloride) 11/19/2008 694 days
5,002,953 AVANDIA (rosiglitazone maleate) 8/30/2008 1113 days
5,004,758 HYCAMTIN  (topotecan HCl) 4/2/2008 786 days
5,006,528 ABILIFY (aripiprazole) 10/20/2009 5 years
5,006,530 BAYCOL ( cerivastatin sodium) 1/17/2009 890 days
5,008,256 TRITEC  (ranitidine bismuth citrate) 7/17/2009 387 days
5,010,090 GABITRIL (tiagabine hydrochloride) 4/23/2008 1255 days
5,015,247 BAK (Interbody Fusion System) 6/13/2008 829 days
5,019,583 ULTIVA  (remifentanil HCl) 2/15/2009 512 days
5,021,458 MENTAX  (butenafine HCl) 6/4/2008 866 days
5,023,269 CYMBALTA (duloxetine HCl) 6/11/2008 5 years
5,034,230 ALAMAST (pemirolast potassium opthalmic solution) 12/23/2008 740 days
5,034,394 ZIAGEN (abacavir) 6/26/2009 905 days
5,041,126 COOK GRII  (Coronary Stent)  3/23/2007 340 days
5,045,302 MYOVIEW  (technetium tc99m tetrafosmin) 4/10/2007 491 days
5,045,552 ACIPHEX (rabeprazole sodium) 9/3/2008 1708 days
5,047,407 EPIVIR  (lamivudine) 2/8/2009 282 days
5,053,407 LEVAQUIN  (levofloxacin) 10/1/2008 810 days 
5,061,703 NAMENDA (memantine HCl) 4/11/2010 5 years
5,070,877 ADENOSCAN  (adenosine) 12/10/2008 159 days
5,075,222 KINERET (recombinant IL-1Ra) 12/24/2008 5 years
5,075,455 DENAVIR (penciclovir) 12/24/2008 639 days
5,079,262 LEVULAN (aminolevulinic acid hydrochloride) 7/28/2009 1525 days
5,089,480 DECTOMAX  (doramectin) 2/18/2009 527 days
5,089,509 TAZORAC (tazaratene) 2/18/2009 845 days
5,095,030 VISUDYNE (verteporfrin) 4/24/2007 1599 days
5,096,890 ENABLEX (darifenacin hydrobromide) 3/13/2010 5 years
5,100,899 RAPAMUNE (sirolimus) 6/6/2009 1492 days
5,101,013 LANTUS (insulin glarginine [rDNA origin]) 3/31/2009 977 days
5,114,923 NATRECOR (nesiritide) 5/19/2009 5 years
5,116,863 PATANOL (olopatadine HCl) 5/26/2009 571 days
5,124,316 GEM 21S 6/23/2009 989 days
5,125,926 HEART LASER™  (CO2 transmyocardial revascularization) 9/24/2010 696 days
5,135,943 ERTACZO (sertaconazole nitrate) cream 8/4/2009 1761 days
5,142,051 VISTIDE  (cidofovir) 8/25/2009 305 days
5,143,724 SYNVISC  (hylan G.F. 20) 7/9/2010 395 days
5,145,863 PHOTOFRIN (porfimer sodium) 6/12/2007 916 days
5,153,222 REMODULIN (trepostinil sodium) 10/6/2009 5 years
5,155,268 CORVERT INJECTION (ibutilide fumerate) 10/13/2009 76 days
5,156,957 GONAL-F (follitropin alpha/beta) 5/8/2007 1605 days
5,158,952 INVEGA (paliperidone) 10/27/2009 895 days
5,162,504 PROSTASCINT 11/10/2009 352 days
5,164,194 ATELIN (azelastine HCl) 11/17/2009 349 days
5,164,402 TROVAN (trovafloxacin mesylate) 11/17/2009 761 days
5,171,569 BENEFIX (coagulation factor IX) 12/15/2009 423 days
5,180,668 REFLUDAN  (lepirudin) 1/19/2010 777 days
5,192,319 Phakic Intraocular Lenses 5/20/2011 1491 days
5,192,808 ANIPRYL (1-Selegiline) 8/31/2010 272 days
5,194,247 SOLAGE (mequinol) 3/16/2010 1365 days
5,196,404 ANGIOMAX (bivalirudin) 3/23/2010 1728 days
5,196,444 ATACAND  (candesartan cilexetil) 4/18/2011 413 days
5,198,533 CETROTIDE (cetrorelix acetate) 7/17/2007 1195 days
5,199,939 Galileo Intravascular Radiotherapy system 4/6/2010 921 days
5,202,333 ALOXI (palonosetron hydrocholoride) 4/13/2010 5 years
5,206,244 BARACLUDE (entecavir) 10/18/2010 1587 days
5,214,052 ACOVA (argatroban) 5/25/2010 1497 days
5,215,895 NEUMEGA  (interleukin-11) 6/1/2010 542 days
5,221,763 RESCULA (unoprostone isopropyl ester) 6/22/2010 754 days
5,223,256 RETAVASE  (reteplase) 10/29/2010 124 days
5,223,510 MULTAQ (dronedarone hydrochloride) 7/26/2011 5 years
5,234,404 GENESA  (arbutamine HCl) 8/10/2010 398 days
5,236,952 TASMAR  (tolcapone) 8/17/2010 530 days
5,246,925 ZEMPLAR  (paricalcitol) 9/21/2010 574 days
5,250,534 VIAGRA  (sildenafil citrate) 6/18/2011 283 days
5,250,542 ENTEREG (alvimopan) 3/29/2011 1826 days
5,254,556 INVEGA SUSTENNA (paliperidone palmitate) 10/27/2009 1449 days
5,258,494 OP-1 Implant 11/2/2010 1525 days
5,260,291 TEMODAR (temozolomide) 11/9/2010 1006 days
5,262,035 FreeStyle Navigator Continuous Glucose Monitoring System 11/16/2010 5 years
5,270,317 AVAPRO  (irbesartan) 9/30/2011 194 days
5,275,813 FEL-O-VAX (FIV vaccine) 1/4/2011 5 years
5,279,811 NEUROLITE  (Technetium Tc99m Bicisate)  3/18/2008 250 days
5,284,858 AMITIZA (lubiprostone) 2/8/2011 1252 days
5,288,726 EFFIENT (prasugrel) 9/8/2012 1679 days
5,292,740 TRACLEER (bosentan) 6/9/2012 1259 days
5,292,756 AGGRASTAT  (tirofiban HCl) 3/8/2011 433 days
5,298,520 MAXALT (rizatriptan benzoate) 1/28/2012 153 days
5,317,016 DORIBAX (doripenem) 8/14/2012 1025 days
5,344,452 ARTEFILL 9/6/2011 5 years
5,344,932 ALIMTA (Pemetrexed) 9/6/2011 1783 days
5,354,330 ATS Open Pivot bileaflet Heart Valve 9/16/2013 928 days
5,356,804 FABRAZYME (agalside beta) 10/18/2011 1440 days
5,360,800 LOTRONEX (alsoetron hydrochloride) 2/2/2010 1076 days
5,360,817 RELENZA (zanamivir) 11/1/2001 633 days
5,360,897 PREVNAR (pneumococcal 7-valent conjugate vaccine) 6/16/2004 1086 days
5,362,718 TORISEL (temsirolimus) 4/18/2014 1764 days
5,362,755 XOPONEX (levalbuterol hydrochloride) 11/8/2011 503 days
5,364,646 VETMEDIN (pimobendan) 11/15/2011 1393 days
5,364,842 PRIALT (ziconotide) 12/30/2011 5 years
5,372,818 EQUIDONE Gel (domiperidone) 2/1/2013 5 years
5,378,703 AZOPT  (brinzolamide ophthalmic suspension) 8/31/2010 723 days
5,380,936 SABRIL (vigabatrin) 12/7/2012 5 years
5,382,518 ELITEK (rasburicase) 1/17/2012 1638 days
5,382,600 DETROL  (tolterodine tartrate) 1/17/2012 68 days
5,385,732 TNKase (tenecteplase) 1/31/2012 853 days
5,387,603 RAPAFLO (Silodosin) 12/1/2013 1825 days
5,405,363 SENTINEL  (implantable cardioverter defibrillator) 4/11/2012 130 days
5,411,552 SAPIEN (transcatheter Heart Valve 9000TFX) 5/2/2012 1420 days
5,418,226 RAPLON (rapacuronium bromide) 4/13/2013 126 days
5,420,319 ELOXATIN (oxaliplatin) 4/7/2013 1220 days
5,424,286 BYETTA (exenatide injection) 5/24/2013 1287 days
5,424,295 ARRANON (nelarabine) 6/13/2012 5 years
5,441,745 Daunoxome (daunorubicin citrate) 5/28/2008 238 days
5,444,106 CeeOn Edge Foldable Ultraviolet Light-Absorbing Posterior Chamber Intraocular Lens- Model 911A 8/22/2012 956 days
5,446,194 COMTAN (entacapone) 9/29/2012 416 days
5,447,926 BESIVANCE (besifloxacin hydrochloride) 9/5/2012 1316 days
5,451,233 XIENCE V Everolimus Eluting cornoary stent system (EECSS) 10/29/2008 777 days
5,453,446 AZILECT (Rasagiline mesylate) 2/7/2012 5 years
5,464,864 FROVA (frovatriptan succinate) 11/7/2012 1096 days
5,468,743 LASTACAFT (alcaftadine) 11/21/2012 1246 days
5,470,932 ACRYSOF (Natual Single-piece Posterior Chamber Intraocular Lens) 10/18/2013 815 days
5,472,438 NeuRx Diaphragm Pacing System 7/22/2013 5 years
5,476,777 RECOTHROM (rh Thrombin) 12/19/2012 954 days
5,478,820 INVANZ (ertapenem sodium) 2/2/2013 1022 days
5,480,668 Neotame 11/9/2013 973 days
5,482,934 OMNARIS (ciclesonide) 1/9/2013 1749 days
5,494,903 TYGACIL (tigecycline) 8/13/2012 1335 days
5,510,106 FEL-O-VAX (LvK FIV vaccine) 1/4/2011 1348 days
5,510,353 ZELNORM (tegaserod maleate) 4/23/2013 1188 days
5,514,650 CANCIDAS (caspofungin acetate) 3/16/2013 681 days
5,514,773 PROFENDER (emodepside/praziquantel) 5/7/2013 814 days
5,521,184 GLEEVEC (imatinib mesylate) 5/28/2013 586 days
5,521,207 DERAMAXX 11/30/2013 883 days
5,527,521 DEFINITY (perflutren lipid microspheres) 4/5/2011 1419 days
5,532,221 Gynecare Intergel  7/2/2013 867 days
5,532,241 VIIBRYD (vilazodone hydrochloride) 9/29/2014 5 years
5,532,372 LATUDA (lurasidone hydrochloride) 7/2/2013 5 years
5,540,938 AMPYRA (dalfampridine) 7/30/2013 5 years
5,545,644 RELPAX (eletriptan) 8/13/2013 1231 days
5,547,853 AMEVIVE (Alefacept) 3/13/2003 1259 days
5,559,111 TEKTURNA (aliskiren hemifumarate) 4/4/2015 1204 days
5,563,146 CYPHER sirolimus-eluting Coronary Stent 4/28/2012 557 days
5,565,447 AXERT (almotriptan malate) 3/28/2014 569 days
5,565,467 AVODART (dutasteride) 10/15/2013 766 days
5,565,473 SINGULAIR  (montelukast sodium) 11/30/2010 430 days
5,567,817 VFEND (voriconazole) 10/22/2013 945 days
5,571,182 Macroplastique Implants 11/2/2010 1664 days
5,591,444 LAVIV (azficel-T) 7/28/2015 5 years
5,595,760 SOMATULINE DEPOT (lanreotide acetate) 3/8/2015 5 years
5,604,213 ZYTIGA (abiraterone acetrate) 2/18/2014 1029 days
5,604,229 GILENYA (fingolimod) 2/18/2014 5 years
5,607,690 FLECTOR PATCH (diclofenac epolamine) 4/13/2014 5 years
5,614,382 PREVNAR 13 (Pneumococcal 13-valetn Conjugate Vaccine) 3/24/2014 1217 days
5,614,520 ULORIC (Febuxostat) 3/25/2014 5 years
5,616,599 BENICAR (olmesartan medoxomil) 4/1/2014 755 days
5,618,913 NOVOLOG (insulin aspart (rDNA origin) injection) 4/8/2014 61 days
5,624,411 ENDEAVOR (zotarolimus eluting coronary stent) 4/29/2014 973 days
5,626,851 ROTATEQ (rotavirus vaccine, live, oral pentavalent) 5/6/2014 1750 days
5,635,485 KETEK (telithromycin) 4/21/2015 1076 days
5,635,517 REVLIMID (lenalidomide) 7/24/2016 1167 days
5,639,443 IMAGENT  (perfluorohexane and DMPC) 6/17/2014 714 days
5,639,639 LUVERIS (lutropin alfa) 6/20/2006 5 years
5,645,599 Coflex interlaminar Technology 4/22/2016 1489 days
5,648,333 FIRAZYR (icatibant acetate)  7/15/2014 5 years
5,656,667 OMACOR (EPA ethyl ester and DHA ethyl ester) 8/12/2014 1476 days
5,658,590 STRATTERA (atomoxetine) 8/19/1997 685 days
5,660,747 CARBON DIOXIDE ETCHING LASER 11/4/2014 5 years
5,661,136 CLOLAR (clofarabine) 8/26/2014 1237 days
5,661,151 NOXAFIL (posaconazole) 8/26/2014 1788 days
5,665,772 AFINITOR (everolimus) 9/9/2014 5 years
5,667,767 ONYX liquid embolic system 7/27/2015 1269 days
5,667,787 DAPTACEL (diphtheria and tetanus toxoids and acellular pertussis vaccine absorbed) 9/16/2014 606 days
5,677,278 KEPIVANCE (palifermine) 10/14/2014 1402 days
5,677,331 COARTEM (artemether & lumefantrine) 10/14/2014 285 days
5,681,814 INCRELEX (mecasermin [rDNA origina]injection) 10/28/2014 1056 days
5,681,818 IPLEX (mecasermin rinfabate [rDNA original injection]) 10/28/2014 1656 days
5,686,411 SYMLIN (pramlintide acetate) 11/11/2014 1586 days
5,688,819 LUMIGAN (bimatoprost) 9/21/2012 698 days
5,691,336 EMEND for Injection (fosaprepitant) 3/4/2014 1826 days
5,693,323 NUCALA (mepolizumab) 12/23/2014 5 years
5,697,896 IONSYS (fentanyl hydrochloride) 12/6/2014 5 years
5,698,558 XYZAL (levocetirizine dihydrochloride) 9/24/2012 305 days
5,711,958 REPEL-CV (PLA-PEG-PLA) 7/11/2016 5 years
5,712,155 ENBREL  (etanercept) 3/7/2012 230 days
5,712,279 JUXTAPID (lomatapide) 2/21/2015 5 years
5,712,298 DALIRESP (roflumilast) 1/27/2015 5 years
5,716,981 TAXUS EXPRESS (paclitaxel-eluting coronary stent system) 2/10/2015 488 days
5,719,147 EMEND (aprepitant) 6/29/2012 1022 days
5,723,606 VAPRISOL (conivaptan hydrochloride) 3/3/2015 1748 days
5,747,498 TARCEVA (erlotinib) 6/6/2015 1251 days
5,750,497 LEVEMIR (insulin detemir) 5/12/2015 1497 days
5,753,646 APTIOM (eslicarbazapine acetate) 6/27/2016 5 years
5,753,677 SAMSCA (tolvaptan) 5/19/2015 5 years
5,762,939 FLUBLOK (seasonal human influenza vaccine) 6/9/2015 5 years
5,763,476 SAPHRIS (asenapine) 6/9/2015 5 years
5,770,599 IRESSA (gefitinib) 4/26/2016 374 days
5,776,456 ZEVALIN (radiolabeled monoclonal antibodies) 7/17/2015 227 days
5,776,944 FACTIVE (gemifloxacin mesylate) 6/15/2015 659 days
5,780,454 VELCADE (bortezomib) 10/28/2014 918 days
5,789,379 GATTEX (teduglutide [rDNA origin]) 4/14/2015 5 years
5,795,911 VEREGEN, aka POLYPHENON, (kunecatechins) Ointment 15% 8/10/2017 1300 days
5,795,965 ACTEMRA (tocilizumab) 8/18/2015 1338 days
5,820,870 GARDASIL (Vaccine for HPV) 10/13/2015 1199 days
5,827,937 RESTYLANE Injectable Gel 7/17/2005 879 days
5,840,299 TYSABRI (natalizumab) 1/25/2014 1188 days
5,840,684 ORBACTIV (oritavancin) 11/24/2015 5 years
5,843,901 PLENAXIS (abarelix) 12/1/2015 725 days
5,847,170 JEVTANA (cabazitaxel) 3/26/2016 5 years
5,849,535 SOMAVERT (pegvisomant for injection) 9/21/2015 551 days
5,849,911 REYATAZ (atazanavir sulfate) 6/20/2003 72 days
5,851,795 ORENCIA (abatacept) 12/1/2015 1413 days
5,852,195 APTIVUS (tipranavir) 12/22/2015 1278 days
5,856,336 LIVALO (pitavastatin) 1/5/2016 1823 days
5,856,346 CLEVIPREX (clevidipine butyrate) 1/5/2016 5 years
5,856,529 HETLIOZ (tasimelteon) 12/9/2017 5 years
5,859,006 CIALIS (tadalafil) 1/12/2016 679 days
5,861,379 EGRIFTA (tesamorelin) 5/26/2015 5 years
5,876,746 ORTHO EVRA (norelgestromin and ethinyl estradiol) 6/7/2015 166 days
5,886,035 ZIOPTAN (tafluprost) 12/18/2017 5 years
5,886,036 KALETRA (lopinavir/ritonavir) 12/29/2012 325 days
5,889,052 TRAVATAN (travoprost) 8/3/2013 486 days
5,900,488 LUZU Cream (luliconazole) 7/5/2016 1291 days
5,914,331 EMTRIVA (emtricitabine) 9/29/2015 642 days
5,925,730 FIRMAGON (Degarelix Acetate) 4/11/2017 1498 days
5,932,211 ELAPRASE (idursulfase) 8/3/2016 1126 days
5,951,974 PEG-INTRON (peginterferon alfa-2b) 11/10/2013 435 days
5,955,079 MENHIBRIX (PSC-TT, PSY-TT and PRP-TT) 9/21/2016 5 years
5,965,138 NAHVAX (Marek's disease vaccine) 10/12/2016 1539 days
5,965,525 ERAXIS (anidulafungin) 10/12/2016 1223 days
5,968,976 FOSRENOL 3/19/2016 951 days
5,968,979 RAVICTI (glycerol phenylbutyrate) 2/7/2015 1267 days
5,980,864 GADAVIST (gadobutrol) 11/9/2016 5 years
5,981,576 PREVICOX (firocoxib) 10/9/2016 651 days
5,984,967 InFuse™ Bone Graft/LT-Cage™ Lumbar Tapered Fusion Device 3/27/2015 464 days
5,985,320 OVUGEL (triptorelin acetate) 3/3/2017 5 years
5,985,844 ZACTRAN (gamithromycin) 11/16/2016 1525 days
6,001,876 LYRICA (pregabalin) 7/16/2017 533 days
6,011,068 SENSIPAR (cinacalcet hydrochloride) 12/14/2016 449 days
6,017,927 VESIcare (solifenacin succinate) 12/27/2015 1058 days
6,020,329 CONVENIA (cefovecin) 1/22/2013 1441 days
6,028,071 FOLOTYN (pralatrexate) 7/16/2017 5 years
6,034,239 ROZEREM (ramelteon) 3/6/2017 868 days
6,034,267 METVIXIA (methyl aminolevulinate) 3/8/2016 871 days
6,039,931 EOVIST (Gadoxetate disodium) 3/21/2017 1698 days
6,051,698 MACUGEN (pegaptanib sodium) 10/17/2012 944 days
6,054,297 AVASTIN (recombinant humanized monoclonal IgG1 antibody) 4/25/2017 307 days
6,063,771 NATROBA (spinosad) 2/22/2019 1494 days
6,083,953 VALCYTE (valganciclovir HCl) 7/28/2014 244 days
6,087,380 PRADAXA (dabogatran etexilate mesylate) 2/18/2018 1409 days
6,090,382 HUMIRA (adalimumab) 2/9/2016 326 days
6,107,458 MYCAMINE (micafungin sodium) NDA 21-506 9/29/2015 1265 days
6,114,319 DUREZOL (difluprednate ophthalmic emulsion) 5/12/2018 371 days
6,118,045 MYOZYME (Alglucosidase alfa) 7/29/2016 750 days
6,133,418 FUZEON (enfuvirtide) 6/7/2013 528 days
6,156,067 BRYAN cervical disc 11/14/2014 5 years
6,197,819 LYRICA (pregabalin) 3/6/2018 300 days
6,204,257 LUSEDRA (fospropofol disodium) 8/7/2018 1424 days
6,208,749 MELAFIND System 2/27/2018 5 years
6,214,865 HALAVEN (eribulin mesylate) 6/16/2019 1495 days
6,217,866 ERBITUX (cetuximab) 1/17/2017 391 days
6,222,038 CERENIA Injectable Solution (maropitant) 4/21/2015 966 days
6,234,772 HVAD rotary blood pump 4/28/2019 1181 days
6,235,030 X-STOP Interspinous Process Decompression System 1/2/2017 1053 days
6,235,883 VECTIBIX (panitumumab) 5/5/2017 1069 days
6,239,180 QUTENZA (capsaicin) 11/6/2016 1671 days
6,245,819 OSPHENA (ospemifene) 7/21/2020 5 years
6,248,775 PREZISTA (darunavir) 8/25/2012 718 days
6,255,320 CERENIA TABLETS (maropitant) 5/8/2020 266 days
6,267,958 XOLAIR (omalizumab) 3/14/2016 463 days
6,268,343 VICTOZA [liraglutide (rDNA origin) injection] 8/22/2017 5 years
6,291,523 ONSIOR (robenacoxib) 9/18/2018 879 days
6,299,604 ZILVER (PTX drug eluting peripheral stent) 8/20/2019 5 years
6,306,141 Talent Abdominal Stent Graft System 10/23/2018 1270 days
6,306,900 MYFORTIC (MYCOPHENOLIC ACID) 4/10/2017 323 days
6,309,402 S8 Over the Wire System 12/19/2014 413 days
6,309,650 IXIARO (Japanese Encephalitis Virus Vaccine, Inactivated, Adsorbed) 8/25/2018 1588 days
6,323,213 VERAFLOX (pradofloxacin) 2/12/2017 1668 days
6,329,404 OSENI (alogliptin benzoate/pioglitazone) 6/19/2016 5 years
6,346,532 MYRBETRIQ (mirabegron) 10/15/2018 1259 days
6,355,245 SOLIRIS (eculizumab) 3/12/2019 735 days
6,395,019 TriVascular Ovation Abdominal Stent Graft System  8/14/2018 5 years
6,395,767 ONGLYZA (saxagliptin) 2/12/2021 895 days
6,403,567 LEXISCAN (regadenoson) 6/22/2019 1024 days
6,407,213 LUCENTIS (ranibizumab) 6/18/2019 378 days
6,410,550 CHANTIX (varenicline tartrate) 11/13/2018 544 days
6,411,852 ALAIR Bronchial Thermoplasty System 4/7/2017 1114 days
6,417,175 TEFLARO (ceftraroline fosamil) 12/18/2018 1211 days
6,420,536 DRAXXIN (tulathromycin) 5/29/2018 360 days
6,441,145 ATRYN (Antithrombin (Recombinant)) 2/21/2015 1270 days
6,441,168 BEYAZ (drospirenone, ethinyl estradiol and levomefolate calcium) 4/17/2020 834 days
6,444,673 LUNESTA (eszopiclone) 1/16/2012 760 days
6,465,504 EXJADE (deferasirox) 6/24/2017 650 days
6,500,829 FUSILEV (levoleucovorin) 12/31/2019 797 days
6,514,946 ZUPREVO (Tildipirosin) 8/29/2020 1482 days
6,534,524 INLYTA (axitinib) 6/30/2020 1764 days
6,538,151 POTIGA (ezogabine) 1/6/2019 1795 days
6,545,040 BYSTOLIC (nebivolol hydrochloride) 4/8/2020 618 days
6,569,837 TYZEKA (telbivudine) 8/10/2019 442 days
6,573,293 PALLADIA (toceranib) 2/15/2021 826 days
6,575,966 Arctic Front Cardiac CryoAblation Catheter System 8/19/2019 1476 days
6,583,272 MIRCERA (methoxy polyethylene glycol-epoetin beta) 8/26/2020 445 days
6,589,508 BROVANA (arformoterol tartrate) 4/3/2012 743 days
6,596,746 SPRYCEL (Dasatinib) 4/13/2020 76 days
6,599,498 FERAHEME (ferumoxytol) 3/8/2020 1209 days
6,602,684 GAZYVA (obinutuzumab) 4/20/2019 946 days
6,602,911 SAVELLA (milnacipran hydrochloride) 11/5/2021 435 days
6,626,858 iStent Trabecular Micro-Bypass Stent 4/26/2020 5 years
6,635,234 XOFIGO (radium -223 dichloride) 1/3/2020 1049 days
6,635,618 VIBATIV (telavancin hydrochloride) 9/22/2021 719 days
6,656,720 FLUCELVAX (influenze Virus Vaccine) 4/1/2017 1477 days
6,656,935 STENDRA (avanafil) 9/13/2020 1687 days
6,664,276 DEXILANT (dexlansoprazole) 6/15/2020 959 days
6,667,314 SELZENTRY (maraviroc) 5/25/2021 73 days
6,673,838 PRISTIQ (desvenlafxine succinate) 2/11/2022 18 days
6,676,929 ABLAVAR (gadofosveset trisodium) 5/26/2015 1805 days
6,709,655 ANAVIP (Crotalidae Immune F(ab')2 (Equine)) 3/5/2021 5 years
6,713,485 TYKERB (lapatinib) 1/8/2019 630 days
6,740,522 PROLIA (denosumab) 12/22/2017 1365 days
6,740,669 BANZEL (rufinamide) 8/17/2020 819 days
6,780,877 BEPREVE (bepotastine besilate) 12/25/2017 633 days
6,783,965 KRYSTEXXA (pegloticase) 8/6/2019 1445 days
6,794,410 AUBAGIO (teriflunomide) 4/1/2022 1625 days
6,810,285 Neuropace RNS System 4/7/2022 5 years
6,818,787 HORIZANT (gabapentin enacarbil) 11/6/2022 882 days
6,835,809 NPLATE (romiplostim) 10/22/2019 820 days
6,858,650 TOVIAZ (fesoteridine fumarate) 5/11/2019 1149 days
6,878,721 ARCAPTA NEOHALER (indacterol maleate) 10/10/2020 1599 days
6,884,434 NEUPRO (ritigotine) 3/18/2019 743 days
6,890,929 APOQUEL (oclacitinib) 6/17/2019 1140 days
6,902,734 STELARA (ustekinumab) 7/27/2022 425 days
6,951,713 INTERCEPT Blood System for Plasma 1/6/2017 5 years
6,967,208 ELIQUIS (apixaban) 2/3/2023 1526 days
6,984,720 YERVOY (ipiilimumab) 8/2/2022 966 days
6,987,103 SYNRIBO (omacetaxine mepesuccinate) 6/28/2012 1216 days
7,008,765 PROGENSA PCA 3 4/9/2018 745 days
7,037,917 INTELENCE (etravirine) 11/5/2019 404 days
7,067,713 RUCONEST (recombinant C1esterase inhibitor (rhC1INH) 2/10/2022 1700 days
7,070,959 EYLEA (aflibercept) 5/23/2020 1119 days
7,090,843 ADCETRIS (brentuximab) (BLA #125388) 11/28/2020 1002 days
7,094,781 OPSUMIT (macitentan) 10/12/2022 1150 days
7,094,874 NULOJIX (belatacept) 4/18/2023 789 days
7,097,840 KADCYLA (ado-trastuzumab) 1/27/2023 1275 days
7,105,530 VOTRIENT (pazopanib) 12/19/2021 669 days
7,125,879 EDURANT (rilpiririne) 4/14/2023 986 days
7,136,699 NOVOTTF-100A System 5/20/2023 689 days
7,138,262 VPRIV (velaglucerase alfa) 8/18/2020 687 days
7,138,501 BENLYSTA (belimumab) 7/9/2023 609 days
7,141,547 TANZEUM (albiglutide) 12/27/2022 1577 days
7,147,851 ENTYVIO (vedolizumab) 7/24/2017 1526 days
7,149,575 Cameron Health S-ICD System 1/31/2022 653 days
7,157,456 XARELTO (rivaroxaban) 2/8/2021 1356 days
7,160,870 PROMACTA (eltrombopag olamine) 12/8/2021 347 days
7,173,037 ADEMPAS (riociguat) 4/25/2023 1319 days
7,176,220 STRIBILD (cobicistat, ELVITEGRAVIR, emtriccitabine, tenofovirdisoproxil fumarate) 11/20/2023 1011 days
7,183,254 MYALEPT (metreleptin for injection) 8/2/2023 1445 days
7,196,205 CERDELGA (eligustat) 4/29/2022 1519 days
7,199,223 ADYNOVATE ((antihemophilic factor (recombinant) pegylated) 2/26/2024 708 days
7,223,593 IMLYGIC (talimogene laherparepvec) 1/22/2021 1766 days
7,230,098 XALKORI (crizotinib) 3/25/2025 178 days
7,270,800 VIZAMYL (flutemetamol F18 injections) 1/24/2023 953 days
7,276,480 KALBITOR (ecallantide) 6/6/2023 178 days
7,304,036 LINZESS (linaclotide) 1/28/2024 945 days
7,341,744 FULYZAQ (crofelemer) 6/2/2022 1075 days
7,348,004 ALPROLIX (Coagulation factor IX (recombinant)) 7/19/2024 1326 days
7,348,361 CYSVIEW (hexaminolevulinate hydrochloride) 4/22/2019 564 days
7,351,533 CERVARIX (Human Papillomavirus Bivalent (Types 16 and 18) Vaccinek,  Recombinant) 9/5/2017 563 days
7,351,834 STIVARGA (regorafenib) 1/12/2020 898 days
7,378,423 MEKINIST (trametinib dimethyl sulfoxide) 9/13/2025 718 days
7,404,956 ELOCTATE (recombinant DNA derived antihemophilic factor) 7/3/2025 740 days
7,407,955 TRADJENTA (linagliptin) 8/12/2023 629 days
7,410,656 PICATO (ingenol mebutate) 8/19/2018 783 days
7,414,105 OMONTYS (peginesatide) 5/12/2024 684 days
7,417,042 KYPROLIS (carfilzomib) 6/7/2026 462 days
7,427,638 OTEZLA (apremilast) 11/17/2024 1186 days
7,439,393 BREO ELLIPTA (vilanterol and fluticasone furoate) 9/11/2022 983 days
7,445,775 JETREA (ocriplasmin) 10/30/2024 717 days
7,452,966 TRULICITY (dulaglutide) 7/6/2024 1249 days
7,473,761 SIGNIFOR (pasireotide diaspartate) 7/29/2025 871 days
7,476,389 GARDASIL 9 (Vaccine for HPV) 1/13/2026 1062 days
7,488,827 ANORO ELLIPTA (umeclidinium/vilanterol) 4/27/2025 965 days
7,498,343 SIRTURO (bedaquiline) 10/2/2024 790 days
7,498,414 CYRAMZA (ramucirumab) 3/9/2023 1059 days
7,511,131 KYNAMRO (mipomersen sodium) 12/13/22025 412 days
7,534,441 IMPROVEST (Gonadotropin releasing factor analog-diptheria toxoid conjugate) 7/9/2018 365 days
7,572,619 NUWIQ (rAHF) 3/21/2021 1337 days
7,579,473 COMETRIQ (cabozatinib) 9/24/2024 689 days
7,615,532 TRESIBA (insulin degludec injection) 7/22/2024 1802 days
7,645,602 IXINITY (coagulation factor IX) 9/23/2024 1527 days
7,668,599 Argus II Visual Stimulation System 3/14/2019 870 days
7,671,032 OLYSIO (simeprevir) 5/19/2025 801 days
7,709,610 EMPLICITI (elotuzumab) 3/13/2026 1096 days
7,807,155 COSENTYX (secukinumab) 5/3/2027 1013 days
7,820,671 INCIVEK (telaprevir) 2/25/2025 87 days
7,828,766 XIENCE Xpedition Stent System 6/9/2026 178 days
7,829,531 ADCETRIS (brentuximab) (BLA #125399) 10/31/2023 229 days
7,862,817 PERJETA (pertuzumab) 6/13/2024 353 days
7,906,119 raxibacumab 6/25/2023 640 days
7,951,557 ELELYSO (taliglucerase alfa) 7/30/2024 336 days
8,008,449 OPDIVO (nivolumab) 9/6/2018 552 days
8,101,194 TRUMENBA (meningooccal group B vaccine) 8/11/2024 573 days
8,017,733 PLEGRIDY PEN (peginterferon beta-1a) 5/25/2025 763 days
8,062,345 RELAY Thoracic Stent-Graft 2/9/2026 224 days
8,173,663 NESINA (alogliptin benzoate) 3/15/2025 262 days
8,183,274 XTANDI (enzalutamide) 5/15/2026 101 days
8,198,262 POMALYST (pomalidomide) 10/19/2024 241 days
8,222,219 INVOKANA (canaglifozin) 7/30/2024 255 days
8,226,710 Medtronic CoreValve System 5/13/2025 360 days
8,273,360 BEXSERO (meningococcal gropu B vaccine) 8/6/2025 518 days
8,288,539 KAZANO (alogliptain benzoate/metformin hydrochloride) 3/15/2025 101 days
8,419,788 SUPERA peripheral stent system 10/22/2027 158 days
       
    *The expiration date listed is the expiration date as of the date of the certificate of extension. It does not take into consideration any terminal disclaimers filed after grant of the certificate of extension.