| US 7,470,671 B2 | ||
| Thioxylose compounds, preparation method thereof, pharmaceutical compositions containing same and use thereof in therapeutics | ||
| Véronique Barberousse, Hauteville-les-Dijon (France); Soth Samreth, Daix (France); Benaïssa Boubia, Saint Apollinaire (France); François Bellamy, Saulon-la-Rue (France); and Vincent Peyrou, Hauteville les Dijon (France) | ||
| Assigned to Laboratoire Fournier, Dijon (France) | ||
| Appl. No. 10/572,999 PCT Filed Sep. 24, 2004, PCT No. PCT/FR2004/002409 § 371(c)(1), (2), (4) Date Mar. 23, 2006, PCT Pub. No. WO2005/030785, PCT Pub. Date Apr. 07, 2005. |
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| Claims priority of application No. 03 11264 (FR), filed on Sep. 25, 2003. | ||
| Prior Publication US 2007/0054955 A1, Mar. 08, 2007 | ||
| Int. Cl. A61K 31/70 (2006.01); A61K 31/7042 (2006.01); C07H 17/02 (2006.01) | ||
| U.S. Cl. 514—27 [514/25; 514/432; 536/17.6; 536/17.5; 536/17.9; 536/18.5; 536/55.3; 549/28] | 12 Claims |
| 1. Thioxylose compounds, wherein the compounds are selected from:
a) the compounds of the formula
 in which:
the pentapyranosyl group is a 5-thio-β-D-xylopyranosyl group or a 5-thio-β-L-xylopyranosyl group,
R is a hydrogen atom, a C2-C6 acyl group, an acetyl group substituted by a nitrogen heterocycle, or a group —COOR′,
R1 and R2 independently of one another are each a hydrogen atom, a halogen atom, a cyano, nitro or trifluoromethyl group, a C1-C4 alkyl group optionally substituted by an aromatic ring, a group —COOR′, a group —CH2—NR′R″, a C1-C4 alkoxy group, a group —NH—CO—R′ or a group —NH—SO2—R′, and
R′ and R″ independently are each a C1-C4 alkyl group; and
b) their addition salts, oxides or quaternary ammonium salts.
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