	US 7,468,439 B2
	Alkylene bridged sultam compounds useful as modulators of nuclear hormone receptor function
Weifang Shan, Princeton, N.J. (US); James Aaron Balog, Lambertville, N.J. (US); Andrew James Nation, Scotch Plains, N.J. (US); Ashvinikumar V. Gavai, Princeton Junction, N.J. (US); Wen-Ching Han, Newtown, Pa. (US); and Mark E. Salvati, Pennington, N.J. (US)
Assigned to Bristol-Myers Squibb Company, Princeton, N.J. (US)
Filed on Sep. 05, 2007, as Appl. No. 11/850,070.
Claims priority of provisional application 60/953217, filed on Aug. 01, 2007.
Claims priority of provisional application 60/842541, filed on Sep. 06, 2006.
Prior Publication US 2008/0090883 A1, Apr. 17, 2008
Int. Cl. C07D 275/04 (2006.01); A61K 31/425 (2006.01)

U.S. Cl. 548—207 [514/373]

12 Claims

1. A compound of the following formula (I):

or a pharmaceutically-acceptable salt thereof;wherein the symbols have the following meanings and are, for each occurrence, independently selected:

G is aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein G is attached to the N atom of the core rings via a carbon atom of G;

A is CR⁴R⁵, C(═O), C(OR⁴)R⁵, CR⁴R⁵CR⁴R⁵, CR⁴R⁵C(═O), or CR⁴R⁵C(OR⁴)R⁵;

Z¹and Z²are each independently H, halogen, CN, alkyl, substituted alkyl, alkenyl, substituted alkenyl, cycloalkyl, substituted cycloalkyl, cycloalkylalkyl, substituted cycloalkylalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocyclo, substituted heterocyclo, heterocycloalkyl, substituted heterocycloalkyl, —C(═O)OR⁶, —C(═O)R⁶, —C(═O)NR⁶R⁷, —OC(═O)NR⁶R⁷, —OC(═O)R⁶, —OR⁶, —C(═N—CN)NR⁶R⁷, —NR⁶C(═O)OR⁷, —NR⁶C(═O)R⁷, —SO₂R⁷, —NR⁶R⁷, —NR⁶SO₂R⁷, —NR⁶SO₂NR⁶R⁷, and/or —NR⁶C(═O)NR⁶R⁷;

Q¹, Q², Q³, and Q⁴are each independently H, halogen, CN, alkyl, substituted alkyl, aryl, substituted aryl, heterocyclo, substituted heterocyclo, —OR⁶, —NR⁶R⁷, —NR⁶C(═O)OR⁷, —OC(═O)NR⁶R⁷, —NR⁶SO₂R⁷, —SO₂R⁷, —OSO₂R⁷, —SO₂NR⁶R⁷, —NR⁶SO₂NR⁶R⁷, —SR⁹, —SOR⁹, —C(═O)NR⁶R⁷, —C(═O)OR⁶, —C(═O)R⁶, —NR⁶C(═O)R⁷, and/or —NR⁶C(═O)NR⁶R⁷; or Q¹and Q²together form O and/or Q³and Q⁴together form O; or Q²and Q⁴together form CR⁶R⁷, O, NR⁸, or a carbon-carbon bond;

R¹and R²are each independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloalkylalkyl, substituted cycloalkylalkyl, alkenyl, substituted alkenyl, arylalkyl, substituted arylalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, OH, and/or CN;

each R³is independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, cycloalkyl, substituted cycloalkyl, cycloalkylalkyl, substituted cycloalkylalkyl, —COR⁶, —CONR⁶R⁷, —OR⁶, —C(═O)OR⁶, —OC(═O)NR⁶R⁷, —SO₂R⁷, —NR⁶C(═O)R⁷, —NR⁶SO₂R⁷, —NR⁶C(═O)NR⁶R⁷, —NR⁶C(═O)OR⁷, and/or —NR⁶R⁷;

each R⁴and each R⁵are independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloalkylalkyl, substituted cycloalkylalkyl, arylalkyl, substituted arylalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, and/or CN; or R⁴and R⁵together with the carbon atom to which they are attached form a cycloalkyl ring;

each R⁶and each R⁷are independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloalkylalkyl, substituted cycloalkylalkyl, arylalkyl, substituted arylalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, and/or CN;

R⁸is H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloalkylalkyl, substituted cycloalkylalkyl, —C(═O)R⁶, —C(═O)NR⁶R⁷, —C(═O)OR⁶, —SO₂R⁷, —SO₂NR⁶R⁷, or —SO₃R⁷; and

each R⁹is independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloalkylalkyl, substituted cycloalkylalkyl, arylalkyl, substituted arylalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, and/or substituted heteroaryl;

with the proviso that when Q²and Q⁴together form a carbon-carbon bond and A¹is CH₂, then G is not a phenyl group substituted at the 4-position with an oxygen-substituted methylene group or —C(═O)O-alkyl.