US 7,468,422 B2
	Mechanosensitive mammalian potassium channel activatable by polyunsaturated fatty acids
Eric Honore, Juan les Pins (France); Michel Fink, Fresne (France); Michel Lazdunski, Nice (France); Florian Lesage, Nice (France); and Fabrice Duprat, Vallauris (France)
Assigned to Centre National de la Recherche Scientifique - CNRS, (France)
Filed on Sep. 12, 2005, as Appl. No. 11/224,260.
Application 11/224260 is a division of application No. 09/655272, filed on Sep. 05, 2000, granted, now 6,942,979.
Application 09/655272 is a continuation of application No. PCT/FR99/00404, filed on Feb. 23, 1999.
Claims priority of application No. 98 02725 (FR), filed on Mar. 05, 1998.
Prior Publication US 2006/0024729 A1, Feb. 02, 2006
Int. Cl. C07K 14/435 (2006.01); C07K 14/705 (2006.01); C07H 21/04 (2006.01); C12N 5/00 (2006.01); G01N 33/53 (2006.01)

U.S. Cl. 530—350  [536/23.1]

7 Claims

1. A purified protein comprising a mechanosensitive potassium channel comprising four transmembranal segments and two P domains activated by at least one polyunsaturated fatty acid and riluzole where the purified protein is selected from the group consisting of a purified protein encoded by the nucleic acid sequence of SEQ ID NO: 1, a purified protein comprising the amino acid sequence of SEQ ID NO: 2, and a purified protein comprising an amino acid sequence having at least 95% identity to the amino acid sequence of SEQ ID NO: 2.