| US 7,468,389 B2 | ||
| Carboxylic acid compound having cyclopropane ring | ||
| Tomoyuki Nishizaki, Kobe (Japan); and Akito Tanaka, Osaka (Japan) | ||
| Assigned to Tox K.K., Kobe-shi (Japan); and Tomoyuki Nishi, Kobe-shi (Japan) | ||
| Appl. No. 10/450,816 PCT Filed Dec. 18, 2001, PCT No. PCT/JP01/11066 § 371(c)(1), (2), (4) Date Jun. 18, 2003, PCT Pub. No. WO02/50013, PCT Pub. Date Jun. 27, 2002. |
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| Claims priority of application No. PR2157 (AU), filed on Dec. 19, 2000. | ||
| Prior Publication US 2005/0075393 A1, Apr. 07, 2005 | ||
| Int. Cl. A61K 31/215 (2006.01); C07C 61/00 (2006.01); C07C 61/04 (2006.01) | ||
| U.S. Cl. 514—531 [562/506; 562/510] | 8 Claims |
| 1. A method for reducing the severity of dementia that is ameliorated by increasing LTP-like potentiation of synaptic transmission
comprising:
administering to a mammalian subject in need thereof an amount of a carboxylic acid compound having one or more cyclopropane
rings of the formula (I), or a pharmaceutically acceptable salt thereof, effective to increase LTP-like potentiation of synaptic
transmission;
wherein formula (I) is:
 wherein R is alkyl selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl,
pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl,
eicosanyl and docosanyl; wherein R may have 1,2-cylcopropylene in a carbon chain and/or cyclopropyl at the end of a chain;
or
R is:
 in which
R′ is hydrogen or alkyl selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl,
tert-butyl, and pentyl,
Y is a single bond or alkylene,
A is 1,2-cyclopropylene or vinylene, and
m is an integer from 0 to 5;
wherein the 1,2-cyclopropylene which may be contained in R may have an alkyl selected from the group consisting of methyl,
ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, tert-pentyl, and hexyl at the 3-position carbon
atom;
X is a single bond or alkylene; and
the total number of carbon atoms minus the number of cyclopropane ring(s) in the compound of formula (I) is 10-25.
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