| US 7,468,388 B2 | ||
| Dimeric compounds and their use as anti-viral agents | ||
| Betty Jin, Mount Waverley (Australia); Simon J. F. MacDonald, Stevenage (United Kingdom); Darryl McConnell, Vienna (Austria); Van T. T. Nguyen, Noble Park (Australia); Stephen E. Shanahan, Stevenage (United Kingdom); and Wen-Yang Wu, Mount Waverley (Australia) | ||
| Assigned to Biota Scientific Management Pty Ltd., Victoria (Australia) | ||
| Filed on Apr. 12, 2007, as Appl. No. 11/734,394. | ||
| Application 11/734394 is a continuation of application No. 10/494260, granted, now 7,223,790, previously published as PCT/AU02/01527, filed on Nov. 08, 2002. | ||
| Claims priority of application No. PR8794 (AU), filed on Nov. 09, 2001. | ||
| Prior Publication US 2007/0225358 A1, Sep. 27, 2007 | ||
| Int. Cl. A61K 31/351 (2006.01) | ||
| U.S. Cl. 514—459 | 9 Claims |
1. A method for the prophylaxis of an orthomyxovirus or paramyxovirus infection comprising the step of administration to a
subject in need thereof of an effective amount of a compound of formula (I)
 R is an amino or guanidino group;
R2 is acetyl or trifluoroacetyl;
X is CONH, NHCO or O;
n is an integer from 2 to 6; and
Y is C2-C8 alkyl, C3-C8 cycloalkyl, C1-C4 alkoxyalkyl, an amino acid or dipeptide,
or a pharmaceutically acceptable salt, ether, ester or salt of such ester thereof,
with the proviso that when R is a guanidino group, R2 is acetyl, X is O and n is 2, then Y is not C2 alkyl.
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