| US 7,465,796 B2 | ||
| Transition metal complexes with (pyridyl)imidazole ligands | ||
| Fei Mao, Fremont, Calif. (US); and Adam Heller, Austin, Tex. (US) | ||
| Assigned to Abbott Diabetes Care Inc., Alameda, Calif. (US) | ||
| Filed on Feb. 24, 2006, as Appl. No. 11/361,427. | ||
| Application 11/361427 is a continuation of application No. 10/714835, filed on Nov. 14, 2003, granted, now 7,074,308. | ||
| Application 10/714835 is a continuation of application No. 10/143300, filed on May 09, 2002, granted, now 6,676,816. | ||
| Claims priority of provisional application 60/290537, filed on May 11, 2001. | ||
| Prior Publication US 2006/0149067 A1, Jul. 06, 2006 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. C07F 15/00 (2006.01); G01N 27/327 (2006.01) | ||
| U.S. Cl. 546—2 [204/403.14; 204/403.04; 502/167] | 19 Claims |
| 1. A sensor control unit, comprising:
a housing adapted for placement on skin and adapted to receive a portion of an electrochemical sensor extending out of the
skin having a plurality of contacts;
a plurality of conductive contacts disposed on the housing and configured for coupling to the plurality of contacts on the
electrochemical sensor; and
an rf transmitter disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained
using the electrochemical sensor,
wherein the electrochemical sensor comprises:
a working electrode;
a counter electrode;
an enzyme disposed proximate to the working electrode; and
a complex disposed proximate to the working electrode, the complex having the formula:
 wherein c is a negative, neutral, or positive charge represented by −1 to −5, 0, or +1 to +5, inclusive, respectively;
M is osmium;
L1 has the formula:
 wherein R7 is a substituted or unsubstituted aryl or a substituted or unsubstituted C1-C12 alkyl;
R8 is —H or Cl alkyl; and
a combination of R9 and R10 forms a fused, saturated or unsaturated, 5- or 6-membered ring;
L2 is a halide; and
L and L′ are independently:
 wherein R′1 is a substituted or an unsubstituted C1-C6 alkyl;
R′3 and R′4 are independently —H; and Ra, Rb, Rc, and Rd are independently —H or Cl alkyl;
wherein said complex is coupled to a polymeric backbone through one or more of L, L′, L1 and L2.
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