| US 7,465,719 B2 | ||
| Carbamic acid compounds comprising an ester or ketone linkage as HDAC inhibitors | ||
| Paul W. Finn, Abingdon (United Kingdom); Ivars Kalvinsh, Riga (Latvia); Einars Loza, Riga (Latvia); Aleksandrs Gutcaits, Riga (Latvia); Irena Olutnika, Riga (Latvia); Ludmila Serpionova, Riga (Latvia); Vija Gailite, Riga (Latvia); and Rasma Bokaldere, Riga (Latvia) | ||
| Assigned to Topotarget UK Limited, Abingdon (United Kingdom) | ||
| Appl. No. 10/542,281 PCT Filed Jan. 19, 2004, PCT No. PCT/GB2004/000147 § 371(c)(1), (2), (4) Date Jul. 15, 2005, PCT Pub. No. WO2004/065354, PCT Pub. Date Aug. 05, 2004. |
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| Claims priority of provisional application 60/440616, filed on Jan. 17, 2003. | ||
| Prior Publication US 2006/0058282 A1, Mar. 16, 2006 | ||
| Int. Cl. A61K 31/55 (2006.01); A61K 31/445 (2006.01) | ||
| U.S. Cl. 514—210.01 [546/229; 562/621] | 53 Claims |
1. A compound of the formula:
 wherein:
J is a linking functional group and is independently:
—C(═O)- or —O—C(═O)— or —C(═O)—O—;
Cy is a cyclyl group and is independently:
C3-20carbocyclyl, C3-20heterocyclyl, or C5-20aryl;
and is optionally substituted;
Q1 is a cyclyl leader group, and is independently a divalent bidentate group obtained by removing two hydrogen atoms from a ring
carbon atom of a saturated monocyclic hydrocarbon having from 4 to 7 ring atoms, or by removing two hydrogen atoms from a
ring carbon atom of saturated monocyclic heterocyclic compound having from 4 to 7 ring atoms including 1 nitrogen ring atom
or 1 oxygen ring atom; and is optionally substituted;
If J is—O—C(═O)— or C(═O)—O—, then:
Q2 is an acid leader group, and is independently:
C1-8 alkylene;
and is optionally substituted; or:
Q2 is an acid leader group, and is independently:
C5-20arylene;
C5-20arylene-C1-7alkylene;
C1-7alkylene-C5-20arylene; or,
C1-7alkylene-C5-20arylene-C1-7alkylene;
and is optionally substituted;
if J is—C(═O)—, then:
Q2 is an acid leader group, and is independently:
C5-20arylene;
C5-20arylene-C1-7alkylene;
C1-7alkylene-C5-20arylene; or,
C1-7alkylene-C5-20arylene-C1-7alkylene;
and is optionally substituted;
and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof.
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