US 7,465,445 B2
	Methods of preventing or treating graft versus host reaction by administering an antibody or portion thereof that binds to AILIM
Katsunari Tezuka, Kanagawa (Japan); Yoshihiro Watanabe, Kanagawa (Japan); and Ryo Abe, Chiba (Japan)
Assigned to Japan Tobacco Inc., Tokyo (Japan)
Filed on Dec. 05, 2003, as Appl. No. 10/729,880.
Application 10/729880 is a continuation of application No. 09/830548, abandoned, previously published as PCT/JP00/05868, filed on Aug. 30, 2000.
Claims priority of application No. 11-242672 (JP), filed on Aug. 30, 1999; and application No. 2000-254680 (JP), filed on Aug. 24, 2000.
Prior Publication US 2004/0229790 A1, Nov. 18, 2004
Int. Cl. A61K 39/395 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01)

U.S. Cl. 424—130.1  [424/133.1; 424/135.1; 424/141.1; 424/142.1; 424/143.1; 530/387.1; 530/387.3; 530/388.1; 530/388.15; 530/388.2]

4 Claims

1. A method of preventing or treating graft versus host reaction in a subject, the method comprising administering to the subject an effective amount of a composition comprising (a) an antibody or a portion thereof that binds to human AILIM and inhibits proliferation of an AILIM-expressing cell or production of interferon-gamma or interleukin-4 by an AILIM-expressing cell, and (b) a pharmaceutically acceptable carrier.