US 7,465,444 B2
	Methods of suppressing or treating an inflammatory bowel disease by administering an antibody or portion thereof that binds to AILIM
Mamoru Watanabe, Tokyo (Japan)
Assigned to Japan Tobacco, Inc., Tokyo (Japan)
Appl. No. 10/472,743 PCT Filed Feb. 18, 2002, PCT No. PCT/JP02/01361 § 371(c)(1), (2), (4) Date Mar. 04, 2004, PCT Pub. No. WO02/076504, PCT Pub. Date Oct. 03, 2002.
Prior Publication US 2004/0131608 A1, Jul. 08, 2004
Int. Cl. A61K 39/395 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01)

U.S. Cl. 424—130.1  [424/133.1; 424/135.1; 424/141.1; 424/142.1; 424/143.1; 530/387.1; 530/387.3; 530/388.1; 530/388.15; 530/388.2]

24 Claims

1. A method of suppressing or treating an inflammatory bowel disease in a subject, the method comprising administering to the subject an effective amount of a composition comprising (a) an antibody or a portion thereof that binds to human AILIM and inhibits proliferation of an AILIM-expressing cell or production of interferon-gamma or interleukin-4 by an AILIM-expressing cell, and (b) a pharmaceutically acceptable carrier.