| US 7,463,921 B2 | ||
| Method and system for analyzing an electrocardiographic signal | ||
| Jean-Philippe Couderc, Rochester, N.Y. (US); Arthur J. Moss, Rochester, N.Y. (US); and Wojciech Zareba, Rochester, N.Y. (US) | ||
| Assigned to University of Rochester, Rochester, N.Y. (US) | ||
| Filed on Aug. 13, 2002, as Appl. No. 10/217,883. | ||
| Claims priority of provisional application 60/311921, filed on Aug. 13, 2001. | ||
| Prior Publication US 2003/0050565 A1, Mar. 13, 2003 | ||
| Int. Cl. A61B 5/0402 (2006.01) | ||
| U.S. Cl. 600—509 | 39 Claims |
| 1. A method for analyzing an effect of a pharmacological agent on an electrocardiogram (ECG) signal, comprising:
obtaining a first ECG signal having at least one beat, the beat having a first repolarization interval represented by a portion
of the first ECG signal from a first T-wave starting point to a first T-wave ending point;
quantifying an area under the first ECG signal during the first repolarization interval;
quantifying a first time to reach at least one percentage of the area under the first ECG signal during the first repolarization
interval;
administering the pharmacological agent;
after administering the pharmacological agent, obtaining a second ECG signal having at least one beat, the beat having a second
repolarization interval represented by a portion of the second ECG signal from a second T-wave starting point to a second
T-wave ending point;
quantifying an area under the second ECG signal during the second repolarization interval;
quantifying a second time to reach the at least one percentage of the area under the second ECG signal during the second repolarization
interval;
detecting an altered ventricular repolarization based on the quantified first and second times.
|