| US 7,462,640 B2 | ||
| Indol-6yl sulfonamide derivatives, their preparation and their use as 5-HT-6 as modulators | ||
| Ramon Merce Vidal, Barcelona (Spain); Xavier Codony Soler, Mataro (Spain); and Alberto Dordal Zueras, Barcelona (Spain) | ||
| Assigned to Laboratorios del Dr. Esteve S.A., Barcelona (Spain) | ||
| Appl. No. 10/566,101 PCT Filed Jul. 29, 2004, PCT No. PCT/EP2004/008510 § 371(c)(1), (2), (4) Date Aug. 10, 2006, PCT Pub. No. WO2005/013976, PCT Pub. Date Feb. 17, 2005. |
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| Claims priority of application No. 200301810 (ES), filed on Jul. 30, 2003. | ||
| Prior Publication US 2007/0043041 A1, Feb. 22, 2007 | ||
| Int. Cl. A01N 43/38 (2006.01); A61K 31/405 (2006.01); C07D 209/04 (2006.01) | ||
| U.S. Cl. 514—415 [548/490; 548/491] | 46 Claims |
1. A sulfonamide compound of general formula (Ia),
 R1 represents a —NR8R9 radical or a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring
member containing cycloaliphatic radical, which may be condensed with a saturated or unsaturated, optionally at least mono-substituted,
optionally at least one heteroatom as a ring member containing mono- or bicyclic cycloaliphatic ring system,
R2, R3, R4, R5 and R7, identical or different, each represent hydrogen, halogen, nitro, alkoxy, cyano, a saturated or unsaturated, linear or branched,
optionally at least mono-substituted aliphatic radical, or an optionally at least mono-substituted phenyl radical or an optionally
at least mono-substituted heteroaryl radical,
R6 represents hydrogen or a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical,
R8 and R9, identical or different, each represent hydrogen or a saturated or unsaturated, linear or branched, optionally at least mono-substituted
aliphatic radical,
with the proviso that R8 and R9 are not hydrogen at the same time, and if one of them, R8 or R9, is a saturated or unsaturated, linear or branched, optionally at least mono-substituted C1-C4 aliphatic radical, the other one is a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic
radical with at least five carbon atoms,
or
R8 and R9, together with the bridging nitrogen atom, form a saturated or unsaturated, optionally at least mono-substituted heterocyclic
ring, which may contain at least one further heteroatom as a ring member and/or which may be condensed with a saturated or
unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono- or
bicyclic cycloaliphatic ring system,
A represents an optionally at least mono-substituted mono- or polycyclic aromatic ring system, which may be bonded via an
optionally at least mono-substituted alkylene, alkenylene or alkynylene group and/or which may contain at least one heteroatom
as a ring member in one or more of its rings
and
n is 0, 1, 2, 3 or 4;
optionally in form of one of its stereoisomers, a racemate or in form of a mixture of at least two of its stereoisomers, in
any mixing ratio, or a salt thereof.
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