	US 7,462,610 B2
	Prostate cancer treatment
Henry A. Lardy, Madison, Wis. (US); Padma Marwah, Albany, Wis. (US); and Ashok Marwah, Albany, Wis. (US)
Assigned to Hollis-Eden Pharmaceuticals, Inc., San Diego, Calif. (US)
Filed on Aug. 11, 2007, as Appl. No. 11/837,508.
Application 11/837508 is a continuation of application No. 10/814503, filed on Mar. 30, 2004, abandoned.
Claims priority of provisional application 60/459450, filed on Apr. 01, 2003.
Prior Publication US 2008/0009472 A1, Jan. 10, 2008
Int. Cl. A61K 31/58 (2006.01)

U.S. Cl. 514—173

16 Claims

1. A method to treat prostate cancer in a subject in need thereof, comprising administering an effective amount of a compound having the structure

wherein

E is —C(O)— or —CR⁵R⁶—;

G is —CR³R⁴—;

K is —CR¹R²—;

R¹is —OR¹¹, —C(O)—R¹², —S(O)_0-2—R¹²or —C(O)—OR¹²;

R²is —H, lower alkyl or substituted lower alkyl;

R³and R⁵independently are —H, —OH or lower alkyl;

R⁴and R⁶independently are —H or substituted lower alkyl;

R¹¹is —H, alkyl or substituted alkyl;

R¹²is —H, alkyl or substituted alkyl;

R is —OH or unsubstituted lower alkoxy;

R′ is —F or unsubstituted lower alkyl;

n is 0 or 1; and

n′ is 0 or 1.