US 7,462,482 B2
	Human smooth muscle myosin heavy chain
Fady Malik, Burlingame, Calif. (US); Christophe Beraud, Palm Springs, Calif. (US); Richard Freedman, San Mateo, Calif. (US); Andrew Craven, Belmont, Calif. (US); Roman Sakowicz, Foster City, Calif. (US); and James Hartman, San Francisco, Calif. (US)
Assigned to Cytokinetics, Inc., South San Francisco, Calif. (US)
Appl. No. 10/486,057 PCT Filed Aug. 09, 2002, PCT No. PCT/US02/25563 § 371(c)(1), (2), (4) Date Feb. 06, 2004, PCT Pub. No. WO03/014323, PCT Pub. Date Feb. 20, 2003.
Application 10/486057 is a continuation in part of application No. 09/927597, filed on Aug. 10, 2001, granted, now 6,974,688.
Prior Publication US 2005/0130143 A1, Jun. 16, 2005
Int. Cl. C12N 1/20 (2006.01); C12N 15/00 (2006.01); C07H 21/04 (2006.01); C12N 9/16 (2006.01)

U.S. Cl. 435—325  [435/410; 435/252.3; 435/254.11; 435/320.1; 435/196; 536/23.1; 536/23.2; 536/23.5; 536/24.31]

7 Claims

1. An isolated nucleic acid encoding a polypeptide, wherein the polypeptide has the following properties: (i) the polypeptide's activity includes (a) ATPase function and (b) the ability to bind actin; and (ii) the polypeptide comprises the amino acid sequence of SEQ ID NO:15 and has at least 98% sequence identity with SEQ ID NO:4 as measured using a sequence comparison algorithm.