CPC C07D 233/64 (2013.01) [A61P 1/16 (2018.01); A61P 9/00 (2018.01); A61P 9/12 (2018.01); A61P 11/00 (2018.01); A61P 13/12 (2018.01); C07D 233/90 (2013.01); C07D 241/04 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 403/04 (2013.01); C07D 403/06 (2013.01); C07D 407/04 (2013.01); C07D 407/06 (2013.01); C07D 409/04 (2013.01); C07D 409/06 (2013.01); C07D 413/04 (2013.01); C07D 413/06 (2013.01); C07D 417/04 (2013.01); C07D 417/06 (2013.01)] | 13 Claims |
1. A compound of the formulae:
wherein:
X is selected from the group consisting of:
R1 to R9 are independently C, N, O or S;
R10 is independently selected from C1-6alkyl, halo, C0-6alkyl carboxylic acid, amino, hydroxy and C1-6alkoxy;
Y is A, CH2-A or CH=A;
A is selected from:
Z is selected from the group consisting of:
R11 is independently selected from halo, alkyl, hydroxy, amino and substituted amino;
R12, R14 and R15 are independently C, CH, CH2, O, N, NH or S;
R13 is C, CH, CH2, N, NH, C—CF3, CH—CF3 or C═O;
m is 0, 1, 2, 3, 4 or 5; and
n is 0, 1, 2, 3 or 4,
or a stereoisomer or pharmaceutically acceptable salt thereof.
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11. A pharmaceutical composition comprising a compound, or a stereoisomer or pharmaceutically acceptable salt thereof, according to claim 1 and a pharmaceutically-acceptable excipient.
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