US 11,833,362 B2
Compositions and methods of altering the electric impedance to an alternating electric field
Hadas Hershkovich, Haifa (IL); Tali Voloshin-Sela, Haifa (IL); and Ze'ev Bomzon, Haifa (IL)
Assigned to NOVOCURE GMBH, Root (CH)
Filed by NOVOCURE GMBH, Root (CH)
Filed on Nov. 30, 2020, as Appl. No. 17/106,531.
Application 17/106,531 is a continuation of application No. 62/946,798, filed on Dec. 11, 2019.
Prior Publication US 2021/0178173 A1, Jun. 17, 2021
Int. Cl. A61N 1/36 (2006.01); A61N 1/40 (2006.01); A61N 1/32 (2006.01); G06T 7/00 (2017.01)
CPC A61N 1/406 (2013.01) [A61N 1/327 (2013.01); A61N 1/36002 (2017.08); G06T 7/0012 (2013.01); G06T 2207/30096 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method of altering the electric impedance to an alternating electric field in a tumor target site of a subject, comprising
a. introducing a conductive nanoparticle to a tumor target site in the subject; and
b. applying an alternating electric field to the tumor target site of the subject,
wherein the electric impedance in the tumor target site of the subject to the alternating current is altered,
wherein the altered electric impedance in the tumor target site of the subject to the alternating current results in an increased mitotic effect of the alternating electric field in the tumor target site.