US 11,833,171 B2
Materials and methods relating to stabilised polymeric silicate compositions
Carlos André Passos Bastos, Cambridge (GB); Jonathan Joseph Powell, Cambridge (GB); Nuno Jorge Rodrigues Faria, Milton Ernest (GB); and Bradley Michael Vis, Cambridge (GB)
Assigned to United Kingdom Research and Innovation, Swindon (GB)
Filed by United Kingdom Research and Innovation, Swindon (GB)
Filed on Dec. 15, 2020, as Appl. No. 17/121,884.
Application 17/121,884 is a division of application No. 16/169,437, filed on Oct. 24, 2018, granted, now 10,898,511.
Application 16/169,437 is a continuation of application No. 15/909,095, filed on Mar. 1, 2018, abandoned.
Application 15/909,095 is a continuation of application No. 15/119,071, abandoned, previously published as PCT/GB2015/050409, filed on Feb. 13, 2015.
Claims priority of application No. 1402672 (GB), filed on Feb. 14, 2014.
Prior Publication US 2021/0145866 A1, May 20, 2021
Int. Cl. A61K 33/00 (2006.01); C08G 77/02 (2006.01); A61K 33/34 (2006.01); A61K 33/38 (2006.01); A61K 9/16 (2006.01); C08K 3/36 (2006.01); A61K 9/00 (2006.01); A61K 47/10 (2017.01); A61K 9/06 (2006.01); A61K 9/48 (2006.01); B82Y 30/00 (2011.01)
CPC A61K 33/00 (2013.01) [A61K 9/0014 (2013.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 9/06 (2013.01); A61K 9/16 (2013.01); A61K 9/1611 (2013.01); A61K 9/4866 (2013.01); A61K 33/34 (2013.01); A61K 33/38 (2013.01); A61K 47/10 (2013.01); C08G 77/02 (2013.01); C08K 3/36 (2013.01); B82Y 30/00 (2013.01); C08K 2201/011 (2013.01)] 34 Claims
 
1. A method of promoting wound healing and/or treating or preventing bacterial infection in a subject, the method comprising administering to the subject a stabilised polymeric silicate composition comprising polymeric silicic acid, poorly condensed nanosilicate particles having mean diameters of 20 nm or less and a stabilising agent comprising a polyalkylene glycol to inhibit formation of condensed silicates, wherein the composition is aquated and is formulated as a cream or an ointment for topical administration, and wherein the pH of the composition is between 5.5 and 8.0.