| US 7,460,914 B2 | ||
| Devices and methods to stimulate therapeutic angiogenesis for ischemia and heart failure | ||
| Evgenia Mandrusov, Santa Clara, Calif. (US); Paul Consigny, San Jose, Calif. (US); and Rodney W. Salo, Fridley, Minn. (US) | ||
| Assigned to Cardiac Pacemakers, Inc., St. Paul, Minn. (US) | ||
| Filed on Oct. 05, 2005, as Appl. No. 11/244,016. | ||
| Application 11/244016 is a division of application No. 10/246249, filed on Sep. 18, 2002, granted, now 7,400,931. | ||
| Prior Publication US 2006/0030810 A1, Feb. 09, 2006 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. A61N 1/05 (2006.01); A61N 1/372 (2006.01); A61M 25/00 (2006.01) | ||
| U.S. Cl. 607—120 [607/3; 604/20; 604/19] | 18 Claims |
| 1. A method for stimulating angiogenesis, comprising:
positioning a first electrode on an implantable first lead at a first intravascular location;
connecting the first lead to an implantable first electrical output channel adapted to deliver a sub-threshold voltage such
that the first electrode is electrically connected to the first electrical output channel, the sub-threshold voltage below
a threshold voltage required to cause a local depolarization of cardiac myocyte cell membranes;
activating the first electrical output channel to deliver the sub-threshold voltage through the first lead to the first electrode;
and
delivering a treatment agent adapted to stimulate therapeutic angiogenesis at the first intravascular location via an implantable
cannula including a lumen configured to deliver a liquid or solid treatment agent to a distal end of the first lead, wherein
the first lead includes at least a portion disposed within the lumen and has an outer diameter that is smaller than an inner
diameter of the cannula to form an annular space suitable for flow of the liquid or solid treatment agent;
wherein the first lead is adapted to deliver the sub-threshold voltage and one or more of pacing or defibrillation voltages
to the first electrode.
|