US 7,459,553 B2
	Process for the preparation of carboxamide compounds
Bobba Venkata Sivakumar, Navi Mumbai (India); Shekhar Bhaskar Bhirud, Navi Mumbai (India); Chandrasekhar Batchu, Navi Mumbai (India); and Sanjay Anantha Kale, Navi Mumbai (India)
Assigned to Glenmark Generics Ltd., Mumbai (India)
Filed on Mar. 11, 2005, as Appl. No. 11/77,723.
Claims priority of provisional application 60/552146, filed on Mar. 11, 2004.
Prior Publication US 2005/0203297 A1, Sep. 15, 2005
Int. Cl. C07D 223/18 (2006.01)

U.S. Cl. 540—589

34 Claims

1. A process for preparing a 5H-dibenz[b,f]azepine-5-carboxamide of the formula: wherein R1, R2, R3 and R4 are the same or different and can be hydrogen, halogen, nitro, cyano, carboxyl, R, —CO(R), —OCO(R), —O(R), —N(R)2, —CON(R)2, and —COO(R), wherein R is selected from the group consisting of C1-C10 alkyl, C3-C10 cycloalkyl, C2-C10 alkenyl, C5-C10 cycloalkenyl, C2-C10 alkynyl, and C6-C20 aryl, and wherein the two R groups of —N(R)2 and —CON(R)2 can be the same or different, and wherein R2 and R3 can together form a bond; the process comprising reacting a 5H-dibenz[b,f]azepine of the formula wherein R1, R2, R3 and R4 have the aforementioned meanings, with one or more alkali or alkaline-earth cyanates and in the presence of one or more unsaturated dicarboxylic acid.