| US 7,459,479 B2 | ||
| Benzylated PDE4 inhibitors | ||
| Ronald W. Lauener, New Westminster (Canada); David L. Burgoyne, Delta (Canada); Patrick J. Rebstein, Vancouver (Canada); Lloyd F. Mackenzie, Surrey (Canada); Yuanlin Zhou, Richmond (Canada); and Yaping Shen, Port Coquitlam (Canada) | ||
| Assigned to Biolipox AB, Solna (Sweden) | ||
| Filed on Mar. 08, 2007, as Appl. No. 11/683,534. | ||
| Application 10/391685 is a division of application No. 09/810085, filed on Mar. 16, 2001, granted, now 6,555,572. | ||
| Application 11/683534 is a continuation of application No. 10/391685, filed on Mar. 18, 2003. | ||
| Claims priority of provisional application 60/190337, filed on Mar. 16, 2000. | ||
| Prior Publication US 2007/0208181 A1, Sep. 06, 2007 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. A61K 31/38 (2006.01); C07D 207/12 (2006.01) | ||
| U.S. Cl. 514—445 [548/543] | 1 Claim |
1. A compound having the following formula:
 Bzl is a benzyl group of the formula
 wherein each of the numerals 1, 2, 3, 4 and 5 is carbon, with the proviso that the ring is aromatic; and
n is 5 and R1 at each occurrence is independently selected from halogen, nitro, R2, and OR2 wherein and R2 at each occurrence is independently selected from H, C1-C8alkyl, alkoxyalkyl having 3-7 carbons in the alkoxy portion and 2-4 carbons in the alkyl portion, phenoxyalkyl having 2-6
carbons in the alkyl portion, C3-C7cycloalkyl, C6-C9polycycloalkyl, alkylcycloalkyl, hydroxyalkyl, carboxylate, alkylcarboxylate, carboxyl, alkyl carboxyl, amide, alkylamide,
phenyl, phenylalkyl having 1-8 carbons in the alkyl portion, phenylaminoalkyl having 2-6 carbons in the alkyl portion and
the amino may be optionally substituted with C1-C4alkyl and indanyl; wherein the alkyl portion of an R2 group may be optionally substituted with one or more fluorine atoms, hydroxyl or C1-C8alkoxy; and the phenyl portion of an R2 group may be optionally substituted with C1-C8alkyl, C1-C8alkoxy or halogen.
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