| US 7,459,467 B2 | ||
| Manufacturing process for methyl phenidate and intermediates thereof | ||
| Ashok Kumar, Mumbai (India); Dharmendra Singh, Thane (India); Swapnali Hemant Patil, Thane (India); Ganesh Devidas Mahale, Mumbai (India); and Uttamrao Arjunrao Sawant, Thane (India) | ||
| Assigned to IPCA Laboratories, Ltd., Mumbai (India) | ||
| Filed on Jun. 10, 2005, as Appl. No. 11/150,737. | ||
| Claims priority of application No. 651/2004 (IN), filed on Jun. 15, 2004. | ||
| Prior Publication US 2005/0277667 A1, Dec. 15, 2005 | ||
| Int. Cl. A61K 31/4458 (2006.01); C07D 211/34 (2006.01) | ||
| U.S. Cl. 514—331 [514/317; 546/238; 546/233] | 16 Claims |
1. A process for reduction of a compound corresponding to the general Formula I, wherein R denotes CONR1R2, COOCH3, or COOH; X denotes hydrogen, Cl, Br, Ome, or NH2; R1 & R2 are independently Hydrogen or C1-C3 alkyl groups,
 a) preparing a reaction mixture by mixing
i) a compound of Formula I, wherein R, X, R1 & R2 are as defined above,
ii) an organic or inorganic acid,
iii) one or more alcoholic solvent, and
iv) palladium catalyst: and
b) effectuating reduction of said reaction mixture in a hydrogen atmosphere to produce a reaction mass comprising compound
of Formula II.
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