US 7,456,318 B2
	Process for preparing benzylated amines
Dennis J. Kalota, Fenton, Mo. (US)
Assigned to Mallinckrodt Inc., Hazelwood, Mo. (US)
Appl. No. 11/722,767 PCT Filed Nov. 02, 2005, PCT No. PCT/US2005/039469 § 371(c)(1), (2), (4) Date Jun. 25, 2007, PCT Pub. No. WO2006/073547, PCT Pub. Date Jul. 13, 2006.
Claims priority of provisional application 60/641843, filed on Jan. 06, 2005.
Prior Publication US 2008/0188685 A1, Aug. 07, 2008
Int. Cl. C07C 209/08 (2006.01); C07C 211/17 (2006.01); C07C 211/27 (2006.01)

U.S. Cl. 564—376  [564/445; 564/454]

32 Claims

1. A process for the preparation of a benzylated amine with the co-production of by-product hydrogen halide, by the reaction of an amine selected from the group consisting of methamphetamine and propylhexedrine with a benzyl halide in a reaction vessel wherein said amine is in molar excess with respect to the benzyl halide and such excess reacts with by-product hydrogen halide to produce an amine halide.