US 7,456,213 B2
PEG-poly(ortho ester) graft copolymers and pharmaceutical compositions
Jorge Heller, Ashland, Oreg. (US)
Assigned to A.P. Pharma, Inc., Redwood City, Calif. (US)
Filed on Mar. 28, 2006, as Appl. No. 11/392,989.
Claims priority of provisional application 60/667880, filed on Mar. 31, 2005.
Prior Publication US 2006/0235083 A1, Oct. 19, 2006
Int. Cl. A61K 31/335 (2006.01); A61K 47/34 (2006.01)
U.S. Cl. 514—452  [424/425; 424/486] 8 Claims
 
1. A graft copolymer of Formula L2:

OG Complex Work Unit Drawing
wherein:
L′ is linker comprising the formula

OG Complex Work Unit Drawing
n is an integer from 2 to 500;
p and q are independently integers from 5 to 100;
R1 is —C1-C4 alkyl;
R and R3 are each independently H or C1-C4 alkyl; and
each A is R5; where: R5 is selected from:

OG Complex Work Unit Drawing
where m′ is an integer from 1 to 6.