US 7,456,027 B2
	Proteolytic biomarkers for traumatic injury to the nervous system
Kevin Ka-Wang Wang, Gainesville, Fla. (US); Ronald Hayes, Gainesville, Fla. (US); Ming Chen Liu, Gainesville, Fla. (US); and Monika Oli, Gainesville, Fla. (US)
Assigned to University of Florida Research Foundation, Inc., Gainesville, Fla. (US); and Banyan Biomarkers, Inc., Alachua, Fla. (US)
Filed on Apr. 15, 2005, as Appl. No. 11/106,932.
Claims priority of provisional application 60/562819, filed on Apr. 15, 2004.
Prior Publication US 2005/0260697 A1, Nov. 24, 2005
Int. Cl. G01N 33/567 (2006.01); G01N 33/48 (2006.01)

U.S. Cl. 436—503  [436/53]

15 Claims

1. A method of determining the presence of neural injury in a subject, comprising detecting at least one or more proteolytic breakdown products of microtubule-associated protein (MAP), wherein the MAP protein is MAP-1, MAP-2A, MAP-2B, MAP-2C, MAP-2D, MAP-3 or MAP-4 in a tissue or fluid sample in contact with injured neural tissue wherein a detectable, amount of the at least one or more breakdown products of MAP is indicative of neural injury in said subject when said amount is greater than in normal subjects without neural injury.