US 7,455,907 B2
Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same
Stephen D. Pacetti, San Jose, Calif. (US); and Syed F. A. Hossainy, Fremont, Calif. (US)
Assigned to Advanced Cardiovascular Systems Inc., Santa Clara, Calif. (US)
Filed on Apr. 11, 2006, as Appl. No. 11/402,392.
Application 11/402392 is a continuation of application No. 10/630250, filed on Jul. 30, 2003, granted, now 7,056,591.
Prior Publication US 2006/0182782 A1, Aug. 17, 2006
This patent is subject to a terminal disclaimer.
Int. Cl. A61F 2/02 (2006.01); A61F 2/06 (2006.01); B32B 27/00 (2006.01); B32B 27/36 (2006.01)
U.S. Cl. 428—411.1  [428/480; 623/1.46; 623/1.49] 19 Claims
 
1. A medical article, comprising an implantable substrate having a coating deposited on the substrate, the coating comprising a polymer, the polymer being a product of co-polycondensation of a diketene acetal and a diol,
wherein the diol comprises, cycloaliphatic, aromatic, or organosilicon diols or blends or combinations thereof where the diketene acetal has a structure of formula (I) or the diol comprises cycloaliphatic, aromatic, or organosilicon diols or blends or combinations thereof where the diketene acetal has a structure of formula (II),
wherein the diketene acetal is selected from a group of compounds having formulae (I) or (II):

OG Complex Work Unit Drawing
wherein:
R, R1, and R3 are, independently, unsusbstituted or substituted straight-chained, branched, or cyclic alkyl radicals C1-C8, or unsusbstituted or substituted aryl radicals;
R2 is a straight chain or branched C1 to C16 alkyl group or a straight chain or branched C1 to C16 alkyl group containing an ether group;
R and R1 are selected such that the diketene acetal is one of 3,9-dipentylidene-2,4,8,10-tetraoxaspiro-[5,5]-heptadecane, 3,9-dibutylidene-2,4,8,10-tetraoxaspiro-[5,5]-pentadecane, 3,9-dipropylidene-2,4,8,10-tetraoxaspiro-[5,5]-tridecane, and mixtures thereof;
wherein the cycloaliphatic diols are selected from a group consisting of 1,2-cyclobutanediol, 1,3-cyclobutanediol, 1,2-cyclopentanediol, 1,3-cyclopentanediol, 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,2-cycloheptanediol, 1,3-cycloheptanediol, 1,4-cycloheptanediol, caprolactone diol, and mixtures thereof; and
wherein the aromatic diols are selected from a group consisting of o-benzenedimethanol, m-benzenedimethanol, and mixtures thereof.