US 7,455,840 B2
	Compositions and methods to reduce mutagenesis
Floyd Romesberg, La Jolla, Calif. (US); Nathaniel E. David, San Francisco, Calif. (US); and Ryan Cirz, San Diego, Calif. (US)
Assigned to The Scripps Research Institute, La Jolla, Calif. (US); and Achaogen, Inc., San Francisco, Calif. (US)
Filed on Nov. 19, 2004, as Appl. No. 10/994,215.
Claims priority of provisional application 60/608949, filed on Nov. 19, 2003.
Prior Publication US 2006/0111302 A1, May 25, 2006
Int. Cl. A61K 31/47 (2006.01); A61K 38/02 (2006.01); A61K 39/40 (2006.01)

U.S. Cl. 424—164.1  [424/150.1; 514/2; 514/18; 514/19; 514/312]

5 Claims

1. A method of inhibiting the evolution of resistance to a quinolone antibiotic in a bacteria comprising administering to the bacteria a quinolone and a composition comprising an agent that inhibits LexA, thereby inhibiting an SOS response pathway in the bacteria.