US 7,455,833 B2
	Methods and compositions for treating viral infections using antibodies and immunoconjugates to aminophospholipids
Philip E. Thorpe, Dallas, Tex. (US); M. Melina Soares, Richardson, Tex. (US); and Sophia Ran, Riverton, Ill. (US)
Assigned to Board of Regents, The University of Texas System, Austin, Tex. (US)
Filed on Aug. 15, 2003, as Appl. No. 10/642,120.
Application 10/642120 is a continuation in part of application No. 10/621269, filed on Jul. 15, 2003.
Claims priority of provisional application 60/396263, filed on Jul. 15, 2002.
Prior Publication US 2004/0131610 A1, Jul. 08, 2004
Int. Cl. A61K 39/00 (2006.01); A61K 38/00 (2006.01)

U.S. Cl. 424—130.1  [424/133.1; 424/141.1; 424/178.1; 424/183.1; 514/2]

118 Claims

1. A method of inhibiting virus replication or spread to additional host cells or tissues, comprising contacting a mammalian cell with an antibody, or antigen-binding fragment thereof, that binds to an aminophospholipid in the absence of serum and serum proteins, in an amount effective to inhibit virus replication in said cell or to inhibit spread to additional host cells or tissues from said cell.