	US 7,452,887 B2
	Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
John K. Dickson, Jr., Apex, N.C. (US); Kevin P. Williams, Chapel Hill, N.C. (US); and Carl Nicholas Hodge, Los Gatos, Calif. (US)
Assigned to Amphora Discovery Corporation, Durham, N.C. (US)
Filed on Jun. 03, 2005, as Appl. No. 11/145,562.
Claims priority of provisional application 60/577224, filed on Jun. 04, 2004.
Prior Publication US 2006/0009460 A1, Jan. 12, 2006
Int. Cl. A61K 31/496 (2006.01); A61K 31/4709 (2006.01); C07D 401/10 (2006.01)

U.S. Cl. 514—253.06 [514/310; 514/313; 544/363; 546/143; 546/160]

42 Claims

1. A compound or Formula 1 or a

pharmaceutically acceptable salt thereof, wherein:

Ar is chosen from aryl, substituted aryl, heteroaryl, and substituted heteroaryl;

A is —N— and B is —CH—, or A is —CH— and B is —N—;

L is chosen from NR¹and O;

R¹is chosen from H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, and substituted heterocycloalkyl;

X and Y are independently chosen from CH and N;

G is chosen from a covalent bond and NR⁶;

R⁶is chosen from hydrogen and optionally substituted alkyl; and

R is chosen from optionally substituted heterocycloalkyl,

with the proviso that when Ar is phenyl, A is —N—, B is —CH—, L is NR¹, R¹is H, X is CH,

Y is CH, and G is a covalent bond, then R is not 4-methylpiperazin-1-yl.