| US 7,452,687 B2 | ||
| Method of detecting mild impaired glucose tolerance or insulin secretory defect | ||
| Masaru Yamakoshi, Mishima (Japan); and Takuji Kouzuma, Mishima (Japan) | ||
| Assigned to Asahi Kasei Pharma Corporation, Tokyo (Japan) | ||
| Appl. No. 10/509,120 PCT Filed Mar. 27, 2003, PCT No. PCT/JP03/03771 § 371(c)(1), (2), (4) Date Nov. 29, 2004, PCT Pub. No. WO03/083133, PCT Pub. Date Oct. 09, 2003. |
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| Claims priority of application No. 2002-097121 (JP), filed on Mar. 29, 2002. | ||
| Prior Publication US 2005/0214885 A1, Sep. 29, 2005 | ||
| Int. Cl. C12Q 1/48 (2006.01); C07C 35/16 (2006.01) | ||
| U.S. Cl. 435—15 [568/833] | 12 Claims |
| 1. A method of detecting mild impaired glucose tolerance or an insulin secretory defect in a subject, wherein the method comprises:
providing urine samples from said subject, wherein the samples are obtained before and after glucose load, or before and after
a meal;
quantitatively determining the myo-inositol level in the samples; and
determining that the subject has mild impaired glucose tolerance or that the subject has an insulin secretory defect based
on the concentration of myo-inositol in the samples,
wherein the increment of the concentration of myo-inositol at a characteristic value or higher than a characteristic value
of 0 to 20 μg myo-inositol per mg creatinine when measured as an increasing amount of myo-inositol excreted in the urine in
a period from 0.5 to 6 hours after 75 g glucose load indicates the subject has mild impaired glucose tolerance or the subject
has an insulin secretory defect.
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