| US 7,452,555 B2 | ||
| Cocrystallization | ||
| Scott L. Childs, Atlanta, Ga. (US) | ||
| Assigned to S.S.C.I., Inc., West Lafayette, Ind. (US) | ||
| Filed on Jan. 21, 2004, as Appl. No. 10/763,987. | ||
| Claims priority of provisional application 60/441561, filed on Jan. 21, 2003. | ||
| Claims priority of provisional application 60/441557, filed on Jan. 21, 2003. | ||
| Prior Publication US 2004/0176335 A1, Sep. 09, 2004 | ||
| Int. Cl. A61K 31/60 (2006.01); A61K 31/19 (2006.01) | ||
| U.S. Cl. 424—666 [562/405] | 11 Claims |
| 1. A method of screening for a cocrystal of a hydrochloric acid salt of an active agent, comprising the steps of:
selecting a carboxylic acid having at least 4 carbons to coordinate via hydrogen bonding with the chloride anion of the hydrochloric
acid salt of the active agent,
preparing a solution, melt, or physical mixture of the hydrochloric acid salt of the active agent and the carboxylic acid,
subjecting the solution or melt to a crystallization process, or the physical mixture to grinding, and
determining whether a cocrystal of the hydrochloric acid salt of the active agent and the carboxylic acid has formed.
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