US 11,816,753 B2
Automated evaluation of human embryos
Hadi Shafiee, Boston, MA (US); Charles Bormann, Boston, MA (US); Manoj Kumar Kanakasabapathy, Boston, MA (US); and Prudhvi Thirumalaraju, Boston, MA (US)
Assigned to THE BRIGHAM AND WOMEN'S HOSPITAL, INC., Boston, MA (US); and THE GENERAL HOSPITAL CORPORATION, Boston, MA (US)
Filed by THE BRIGHAM AND WOMEN'S HOSPITAL, INC., Boston, MA (US); and THE GENERAL HOSPITAL CORPORATION, Boston, MA (US)
Filed on Apr. 12, 2022, as Appl. No. 17/718,508.
Application 17/718,508 is a continuation of application No. 16/651,269, granted, now 11,321,831, previously published as PCT/US2018/053710, filed on Oct. 1, 2018.
Claims priority of provisional application 62/651,658, filed on Apr. 2, 2018.
Claims priority of provisional application 62/565,237, filed on Sep. 29, 2017.
Prior Publication US 2022/0237791 A1, Jul. 28, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. G06T 7/00 (2017.01)
CPC G06T 7/0012 (2013.01) [G06T 2207/10024 (2013.01); G06T 2207/20036 (2013.01); G06T 2207/20081 (2013.01); G06T 2207/20084 (2013.01); G06T 2207/30044 (2013.01)] 32 Claims
OG exemplary drawing
 
1. A method for fully automated evaluation of a human embryo, comprising:
receiving, using a fully automated computer system, an image of the embryo;
generating, using the fully automated computer system and without human directed segmentation, a plurality of values representing a morphology of the embryo from the image of the embryo, wherein the fully automated computer system is trained to generate the plurality of values on a set of images of embryos; and
providing, using the fully automated computer system, an output class representing one of (a) a future quality of the embryo, (b) a likelihood of the embryo's viability upon implantation, or (c) a likelihood that implantation of the embryo will result in a live birth, wherein the fully automated system is trained to evaluate the plurality of values representing the morphology of the embryo and provide the likelihood based on the evaluation of the plurality of values.